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Table 4 Association between levels of antibodies (two-fold increment) at 10.5 months of age and the incidence of malaria up to 24 months of age

From: Impact of age of first exposure to Plasmodium falciparum on antibody responses to malaria in children: a randomized, controlled trial in Mozambique

   10.5-24 months
Antigens Antibodies Crude Adjusted
   IRR1 95% CI P value2 IRR 95% CI P value
MSP-119 IgG 1.26 1.03; 1.55 0.0269 1.15 0.94; 1.40 0.1710
IgG1 1.23 1.01; 1.49 0.0385 1.13 0.94; 1.36 0.2081
IgG2 0.82 0.45; 1.49 0.5226 0.76 0.45; 1.27 0.2968
IgG3 1.19 0.77; 1.82 0.4235 0.94 0.63; 1.39 0.7423
IgG4 1.35 0.75; 2.42 0.3096 1.27 0.69; 2.33 0.4361
IgM 0.98 0.65; 1.49 0.9419 1.01 0.70; 1.45 0.9654
AMA-1 IgG 1.86 1.37; 2.53 < 0.0001 1.31 1.00; 1.72 0.0533
IgG1 1.68 1.26; 2.25 0.0002 1.21 0.94; 1.57 0.1366
IgG2 1.12 0.57; 2.23 0.7446 0.98 0.57; 1.67 0.9354
IgG3 1.06 0.71; 1.59 0.7446 0.98 0.71; 1.33 0.8743
IgG4 2.78 1.13; 6.81 0.0261 1.85 0.83; 4.14 0.1360
IgM 1.65 0.94; 2.87 0.0811 2.08 1.26; 3.45 0.0037
EBA-175 IgG 0.73 0.50; 1.09 0.1235 0.67 0.47; 0.94 0.0178
IgG1 0.75 0.50; 1.13 0.1735 0.75 0.54; 1.04 0.0874
IgG2 0.74 0.50; 1.09 0.1124 0.69 0.50; 0.90 0.0239
IgG3 0.90 0.58; 1.40 0.6580 0.80 0.55; 1.17 0.2469
IgG4 0.89 0.56; 1.41 0.6152 0.75 0.49; 1.14 0.1741
IgM 1.12 0.72; 1.74 0.6113 1.48 1.02; 2.14 0.0358
VSA IgG 1.02 0.76; 1.36 0.8827 0.92 0.68; 1.24 0.5864
  1. Analysis done by negative binomial regression models adjusted by treatment, season, neighbourhood, current infection, previous infection, maternal infection, congenital infection, placental inflammation, insecticide-treated bed net use, and indoor residual spraying.
  2. 1Incidence rate ratio.
  3. 2Negative binomial regression model using likelihood ratio test.