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Table 5 Association between levels of antibodies (two-fold increment) at 15 months of age and the incidence of malaria up to 24 months of age

From: Impact of age of first exposure to Plasmodium falciparum on antibody responses to malaria in children: a randomized, controlled trial in Mozambique

   15-24 months
Antigens Antibodies Crude Adjusted
   IRR1 95% CI P value2 IRR 95% CI P value
MSP-119 IgG 1.56 1.33; 1.82 < 0.0001 1.29 1.06; 1.57 0.0121
IgG1 1.62 1.39; 1.90 < 0.0001 1.37 1.13; 1.66 0.0011
IgG2 2.14 1.07; 4.27 0.0260 1.37 0.71; 2.28 0.4141
IgG3 1.84 1.36; 2.48 < 0.0001 1.32 0.98; 1.77 0.0591
IgG4 2.22 0.79; 6.21 0.1033 1.35 0.60; 3.05 0.4694
IgM 0.83 0.53; 1.31 0.4290 0.84 0.55; 1.27 0.4027
AMA-1 IgG 1.87 1.52; 2.30 < 0.0001 1.43 1.14; 1.79 0.0023
IgG1 1.96 1.61; 2.38 < 0.0001 1.55 1.27; 1.90 < 0.0001
IgG2 2.32 1.21; 4.44 0.0086 1.89 1.12; 3.20 0.0161
IgG3 1.99 1.48,2.67 < 0.0001 1.41 1.08; 1.83 0.0113
IgG4 2.55 1.24; 5.23 0.0088 1.71 0.95; 3.05 0.0723
IgM 0.78 0.45; 1.37 0.3973 0.64 0.39; 1.04 0.0715
EBA-175 IgG 1.48 1.08; 2.04 0.0141 1.14 0.83; 1.57 0.4052
IgG1 1.78 1.19; 2.68 0.0040 1.31 0.91; 1.89 0.1442
IgG2 0.88 0.42; 1.82 0.7257 0.55 0.27; 1.10 0.0898
IgG3 1.80 1.03; 3.15 0.0283 0.96 0.63; 1.48 0.8697
IgG4 1.40 0.62; 3.17 0.4025 0.98 0.51; 1.89 0.9600
IgM 0.65 0.36; 1.17 0.1510 0.72 0.42; 1.20 0.2133
VSA IgG 1.68 1.18; 2.38 0.0034 1.29 0.94; 1.76 0.1105
  1. Analysis done by negative binomial regression models adjusted by treatment, season, neighbourhood, current infection, previous infection, maternal infection, congenital infection, placental inflammation, insecticide-treated bed net use, and indoor residual spraying.
  2. 1Incidence rate ratio.
  3. 2Negative binomial regression model using likelihood ratio test.