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Table 5 Association between levels of antibodies (two-fold increment) at 15 months of age and the incidence of malaria up to 24 months of age

From: Impact of age of first exposure to Plasmodium falciparum on antibody responses to malaria in children: a randomized, controlled trial in Mozambique

  

15-24 months

Antigens

Antibodies

Crude

Adjusted

  

IRR1

95% CI

P value2

IRR

95% CI

P value

MSP-119

IgG

1.56

1.33; 1.82

< 0.0001

1.29

1.06; 1.57

0.0121

IgG1

1.62

1.39; 1.90

< 0.0001

1.37

1.13; 1.66

0.0011

IgG2

2.14

1.07; 4.27

0.0260

1.37

0.71; 2.28

0.4141

IgG3

1.84

1.36; 2.48

< 0.0001

1.32

0.98; 1.77

0.0591

IgG4

2.22

0.79; 6.21

0.1033

1.35

0.60; 3.05

0.4694

IgM

0.83

0.53; 1.31

0.4290

0.84

0.55; 1.27

0.4027

AMA-1

IgG

1.87

1.52; 2.30

< 0.0001

1.43

1.14; 1.79

0.0023

IgG1

1.96

1.61; 2.38

< 0.0001

1.55

1.27; 1.90

< 0.0001

IgG2

2.32

1.21; 4.44

0.0086

1.89

1.12; 3.20

0.0161

IgG3

1.99

1.48,2.67

< 0.0001

1.41

1.08; 1.83

0.0113

IgG4

2.55

1.24; 5.23

0.0088

1.71

0.95; 3.05

0.0723

IgM

0.78

0.45; 1.37

0.3973

0.64

0.39; 1.04

0.0715

EBA-175

IgG

1.48

1.08; 2.04

0.0141

1.14

0.83; 1.57

0.4052

IgG1

1.78

1.19; 2.68

0.0040

1.31

0.91; 1.89

0.1442

IgG2

0.88

0.42; 1.82

0.7257

0.55

0.27; 1.10

0.0898

IgG3

1.80

1.03; 3.15

0.0283

0.96

0.63; 1.48

0.8697

IgG4

1.40

0.62; 3.17

0.4025

0.98

0.51; 1.89

0.9600

IgM

0.65

0.36; 1.17

0.1510

0.72

0.42; 1.20

0.2133

VSA

IgG

1.68

1.18; 2.38

0.0034

1.29

0.94; 1.76

0.1105

  1. Analysis done by negative binomial regression models adjusted by treatment, season, neighbourhood, current infection, previous infection, maternal infection, congenital infection, placental inflammation, insecticide-treated bed net use, and indoor residual spraying.
  2. 1Incidence rate ratio.
  3. 2Negative binomial regression model using likelihood ratio test.