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Table 2 Genotyping results from isolates in the in vivo therapeutic efficacy study and in vitro drug assay

From: Chloroquine efficacy studies confirm drug susceptibility of Plasmodium vivax in Chennai, India

Study

 

Subjects enrolled (N)

Pvmdr1 haplotypesa

Microsatellite genotyping

Isolates successfully genotyped (n)

958M/Y976/1076L (n (%))

958M/Y976/F1076 (n (%))

Isolates successfully genotyped (n)

Multiclonal infections (n (%))

Clones (n)

Multiplicity of infectionc

in vivo therapeutic efficacy:

       
 

Day 0

125

33

33 (100)

0 (0.0)

33

5 (15.2)

38

1.15

 

Day 3

19

0

-

-

0

-

-

-

 

Day Other

17

15

14 (93.3)

1 (6.7)

17

3b (17.6)

21

1.24

 

Total

125

48

47 (97.9)

1 (2.1)

50

8 (16.0)

59

1.18

in vitro drug assay:

       
 

Group 1

51

9

8 (88.9)

1 (11.1)

10

4 (40.0)

14

1.40

 

Group 2

17

9

9 (100)

0 (0.0)

10

2 (20.0)

12

1.20

 

Total

68

18

17 (94.4)

1 (5.6)

20

6 (30.0)

26

1.30

  1. aGenBank accession nos: KC818349-KC818412; Pvmdr1 haplotype of the CQ sensitive Salvador I reference strain is T958/Y976/F1076.
  2. bOf the three multiclonal infections, two had two alleles at more than one locus (double infection) and one had three alleles at more than one locus (triple infection).
  3. cMultiplicity of infection is the total number of clones detected divided by the total number of infections.