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Table 4 Assessment association between pfdhfr and pfdhps genotypes and treatment outcomes

From: Two novel mutations of pfdhps K540T and I588F, affecting sulphadoxine-pyrimethamine-resistant response in uncomplicated falciparum malaria at Banjar district, South Kalimantan Province, Indonesia

Genotype

Treatment outcomes

95% CI

P

ACPR

ETF/LPF

< quintuple mutants

6

8

1.112-2.755

0.024

≥ quintuple mutants

0

10

Total

6

18

  
  1. Quintuple mutants = the cases containing five mutations of pfdhfr 108N, 59R, 164L and pfdhps 437G, 540E or 540T, 581G.
  2. ACPR = adequate clinical parasitological response; ETF/LPF = parasitological failure.