Table 4 Percentage of individuals with mg/kg doses below or above the therapeutic dose range (according to [30]) of 2–10 mg/kg dihydroartemisinin (DHA) and 16–26 mg/kg piperaquine (PPQ) in each weight- and age-based dosing band
Number of tablets | Â | Age-based dosing regimen | Weight-based dosing regimen | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Â | Â | Global | Africa | Asia | Latin America | Global | Africa | Asia | Latin America |
0.5 × 20/160 mg | n | 1037 | 657 | 1037 | 657 | 99 | 89 | 105 | 35 |
| Â | DHA below | 99.04% | 98.48% | 99.04% | 99.85% | 100.00% | 100.00% | 100.00% | 100.00% |
| Â | DHA above | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% |
| Â | PPQ below | 99.04% | 98.48% | 99.04% | 99.85% | 100.00% | 100.00% | 100.00% | 100.00% |
| Â | PPQ above | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% |
1 × 20/160 mg | n | 2836 | 2825 | 3222 | 2037 | 1343 | 1204 | 1401 | 1003 |
| Â | DHA below | 98.55% | 95.72% | 98.70% | 98.63% | 59.20% | 57.97% | 59.31% | 61.32% |
| Â | DHA above | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% |
| Â | PPQ below | 98.55% | 95.72% | 98.70% | 98.63% | 59.20% | 57.97% | 59.31% | 61.32% |
| Â | PPQ above | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% |
1 × 40/320 mg | n | 2005 | 2396 | 2053 | 1973 | 2946 | 2499 | 3063 | 2106 |
| Â | DHA below | 87.23% | 94.49% | 93.18% | 93.82% | 29.33% | 32.53% | 28.73% | 31.43% |
| Â | DHA above | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% |
| Â | PPQ below | 87.23% | 94.49% | 93.18% | 93.82% | 29.33% | 32.53% | 28.73% | 31.43% |
| Â | PPQ above | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% |
2 × 40/320 mg | n | 4122 | 2104 | 3688 | 2054 | 1908 | 1606 | 1990 | 1462 |
| Â | DHA below | 64.07% | 86.98% | 60.93% | 77.07% | 0.00% | 0.00% | 0.00% | 0.00% |
| Â | DHA above | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% |
| Â | PPQ below | 64.07% | 86.98% | 60.93% | 77.07% | 0.00% | 0.00% | 0.00% | 0.00% |
| Â | PPQ above | 0.05% | 0.00% | 0.00% | 0.15% | 5.56% | 6.79% | 5.48% | 5.54% |
3 × 40/320 mg | n | 0 | 2018 | 0 | 3279 | 3686 | 4491 | 3441 | 5174 |
|  | DHA below | – | 31.27% | – | 39.92% | 6.27% | 16.90% | 1.08% | 24.70% |
|  | DHA above | – | 0.00% | – | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% |
|  | PPQ below | – | 31.27% | – | 39.92% | 6.27% | 16.90% | 1.08% | 24.70% |
|  | PPQ above | – | 0.05% | – | 0.00% | 5.18% | 2.58% | 6.02% | 2.11% |
4 × 40/320 mg | n | 0 | 0 | 0 | 0 | 18 | 111 | 0 | 220 |
|  | DHA below | – | – | – | – | 0.00% | 48.65% | – | 45.00% |
|  | DHA above | – | – | – | – | 0.00% | 0.00% | – | 0.00% |
|  | PPQ below | – | – | – | – | 0.00% | 48.65% | – | 45.00% |
|  | PPQ above | – | – | – | – | 0.00% | 0.00% | – | 0.00% |