Revised zoogeographical zones and observed time to first relapse. Panel A illustrates the revised zoogeographical zones used to describe the time to first relapse. Panel B shows the median observed time to relapse in each study used to obtain individual data. The size of each point varies by sample size and the time to first relapse is shown on a spectrum of red (less than one month) to dark blue (>12 months). Violin plots in Panel C show the observed time to first relapse in individuals from each zone in Panels A and B. The coloured areas correspond to each zone and to a smoothed approximation of the frequency distribution (a kernel density plot) of the time relapse within each geographic region. The black central bar represents the interquartile range and the white circles indicate the median values. Note that the maximum value for zone 2 extends beyond the plot.