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Table 5 Comparisons of IC 50 s of uracil-derived compounds in their inhibitory effects on recombinant PfUDG activity, P. falciparum growth and cytotoxicity to HepG2 cell lines

From: Molecular characterization of Plasmodium falciparum uracil-DNA glycosylase and its potential as a new anti-malarial drug target

No. Compound IC50(μM)
   PfUDG P. falciparum HepG2 cytotoxicity
1 1-Methoxyethyl-6-(p-n-octylanilino)uracil 16.75 15.6 > 160
2 6-(Phenylhydrazino)uracil 77.5 12.8 27.5 ± 4.58
3 6-(p-n-Heptylanilino)uracil > 400 5.0 ND
4 6-(4-Methylanilino)uracil > 400 7.1 ND
5 6-(p-n-Propylanilino)uracil > 400 7.9 ND
6 Uracil > 400 10.0 ND
7 6-(p-n-Butylanilino)uracil > 400 10.0 ND
8 3-(4-Hydroxybutyl)-6-(3-ethyl-4-methylanilino)uracil > 400 10.2 ND
9 6-(p-n-Pentylanilino)uracil > 400 10.5 ND
10 6-(p-i-Pentylanilino)uracil > 400 11.0 ND
11 6-(p-i-Propylanilino)uracil > 400 12.6 ND
12 6-(p-i-Butylanilino)uracil > 400 16.5 ND
  1. ND = not-determined.