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Table 3 The number and frequency of pfcrt , pfmdr1 and pfnhe ms 4760 alleles in Plasmodium falciparum field samples collected in Ujjain, Madhya Pradesh, India in 2009 and 2010

From: Characterization of drug resistance associated genetic polymorphisms among Plasmodium falciparum field isolates in Ujjain, Madhya Pradesh, India

Gene

Polymorphism/no of repeats

Number/total*

Proportion (%)

Pfcrt 76

K

5/87

6

 

T

82/87

94

Pfmdr1

   

86

N

70/83

84

86

Y

13/83

16

1034 + 1042

SN

75/75

100

1246

D

70/72

97

1246

Y

2/72

3

Gene copy number†

1

74/75

99

 

2

1/75

1

Pfnhe ms4760 DNNND repeats

1

14/74

19

2

50/74

68

3

3/74

4

4

7/74

9

Pfnhe ms4760 DDNHNDNHNND Repeats

1

56/74

76

2

18/74

24

  1. * Total number of polymorphisms successfully identified at each locus.
  2. †Pfmdr1 gene copy number was between one and two (ΔΔCt 1.3-1.6) in six samples and PCRs failed in six samples.
  3. All pfmdr1 86Y occurred together with pfcrt 76 T. Pfmdr1 1246Y alleles occurred together with pfcrt 76 T and pfmdr1 N86.