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Table 2 Parameter estimates

From: Population pharmacokinetics of mefloquine, administered as a fixed-dose combination of artesunate-mefloquine in Indian patients for the treatment of acute uncomplicated Plasmodium falciparum malaria

 

Base model

Final model

Parameter

Estimate

SD

Estimate

SD

Ka (h-1)

0.166

0.0266

0.163

0.0263

CL/F (L/h)

1.15

0.0496

1.13

0.0501

Vc/F (L)

279

14.7

271

14.1

ѲBW,Vc

/

/

0.87

0.288

Q/F (L/h)

1.33

0.124

1.43

0.152

Vp/F (L)

341

39

344

40.6

ѲBW,Vp

/

/

2.41

1.08

ω ka 2

0.675

0.250

0.562

0.232

ω CL F 2

0.0939

0.0224

0.0894

0.0218

ω Vc F 2

0.0603

0.0209

0.0453

0.0163

ω Vp F 2

0.401

0.166

0.295

0.128

σ2

0.0689

0.0150

0.0692

0.015

  1. SD standard deviation of the estimate (obtained from the covariance step); Ka: absorption rate constant; CL/F: apparent oral clearance; Vc/F: apparent central distribution volume; ѲBW,Vc: influential factor of BW on Vc/F; Q/F: apparent distribution clearance; Vp/F: apparent distribution volume ; ѲBW,Vp : influential factor of BW on Vp/F ; ω CL F 2 : inter-individual variability of CL/F; ω Vc F 2 : inter-individual variability of Vc/F; ω Vp F 2 : inter-individual variability of Vp/F; ω ka 2 : inter-individual variability of Ka; σ2: proportional residual error.