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Table 2 Parameter estimates

From: Population pharmacokinetics of mefloquine, administered as a fixed-dose combination of artesunate-mefloquine in Indian patients for the treatment of acute uncomplicated Plasmodium falciparum malaria

  Base model Final model
Parameter Estimate SD Estimate SD
Ka (h-1) 0.166 0.0266 0.163 0.0263
CL/F (L/h) 1.15 0.0496 1.13 0.0501
Vc/F (L) 279 14.7 271 14.1
ѲBW,Vc / / 0.87 0.288
Q/F (L/h) 1.33 0.124 1.43 0.152
Vp/F (L) 341 39 344 40.6
ѲBW,Vp / / 2.41 1.08
ω ka 2 0.675 0.250 0.562 0.232
ω CL F 2 0.0939 0.0224 0.0894 0.0218
ω Vc F 2 0.0603 0.0209 0.0453 0.0163
ω Vp F 2 0.401 0.166 0.295 0.128
σ2 0.0689 0.0150 0.0692 0.015
  1. SD standard deviation of the estimate (obtained from the covariance step); Ka: absorption rate constant; CL/F: apparent oral clearance; Vc/F: apparent central distribution volume; ѲBW,Vc: influential factor of BW on Vc/F; Q/F: apparent distribution clearance; Vp/F: apparent distribution volume ; ѲBW,Vp : influential factor of BW on Vp/F ; ω CL F 2 : inter-individual variability of CL/F; ω Vc F 2 : inter-individual variability of Vc/F; ω Vp F 2 : inter-individual variability of Vp/F; ω ka 2 : inter-individual variability of Ka; σ2: proportional residual error.