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Table 1 Cure rates in C57BL/6 wild-type (WT), CYP 2D knock-out, and humanized/CYP 2D6 knock-in mice 31 days post-inoculation with Plasmodium berghei in the absence or presence of NPC-1161B and tafenoquine

From: Tafenoquine and NPC-1161B require CYP 2D metabolism for anti-malarial activity: implications for the 8-aminoquinoline class of anti-malarial compounds

NCP-1161B
i Mouse strain 1161B Dose Cure
  WT - 0/5
  WT ED 100 5/5
  2DKO - 0/5
  2DKO ED 100 0/5
  2DKO/2D6KI ED 100 0/5
Tafenoquine (TQ)
ii Mouse strain TQ Dose Cure
  WT - 0/5
  WT ED 100 5/5
  2DKO - 0/5
  2DKO ED 100 0/5
  2DKO/2D6KI ED 100 0/5
  2DKO/2D6KI 2 × ED 100 4/5
  1. A cure is indicated if there was no detectable parasite burden in blood measurements after 31 days post-inoculation.