Skip to main content

Table 1 Cure rates in C57BL/6 wild-type (WT), CYP 2D knock-out, and humanized/CYP 2D6 knock-in mice 31 days post-inoculation with Plasmodium berghei in the absence or presence of NPC-1161B and tafenoquine

From: Tafenoquine and NPC-1161B require CYP 2D metabolism for anti-malarial activity: implications for the 8-aminoquinoline class of anti-malarial compounds

NCP-1161B

i

Mouse strain

1161B Dose

Cure

 

WT

-

0/5

 

WT

ED 100

5/5

 

2DKO

-

0/5

 

2DKO

ED 100

0/5

 

2DKO/2D6KI

ED 100

0/5

Tafenoquine (TQ)

ii

Mouse strain

TQ Dose

Cure

 

WT

-

0/5

 

WT

ED 100

5/5

 

2DKO

-

0/5

 

2DKO

ED 100

0/5

 

2DKO/2D6KI

ED 100

0/5

 

2DKO/2D6KI

2 × ED 100

4/5

  1. A cure is indicated if there was no detectable parasite burden in blood measurements after 31 days post-inoculation.
Back to article page

Malaria Journal

ISSN: 1475-2875

Contact us