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Table 4 Diagnostic accuracy of Pf HRP2 versus Pf -pLDH by age group and by season

From: Accuracy of Pf HRP2 versus Pf-pLDH antigen detection by malaria rapid diagnostic tests in hospitalized children in a seasonal hyperendemic malaria transmission area in Burkina Faso

  Nr Slide Pf pos (%) Pf HRP2 Pf-pLDH
  SE Sp PPV NPV SE Sp PPV NPV
(95% C.I.) (95% C.I.) (95% C.I.) (95% C.I.) (95% C.I.) (95% C.I.) (95% C.I.) (95% C.I.)
Age (m)           
1 – 11 194 39.7 100.0 70.9 69.4 100.0 98.7 94.0 91.6 99.1
    94.7-100.0 67.4-70.9 65.7-69.4 95.1-100.0 93.5-99.9 90.6-94.8 86.8-92.7 95.5-100.0
12 – 59 401 64.1 100.0 39.6 74.7 100.0 100.0 86.8 93.1 100.0
    98.3-100.0 36.6-39.6 73.5-74.7 92.5-100.0 98.4-100.0 84.0-86.8 91.6-93.1 96.7-100.0
≥ 60 99 42.4 100.0 68.4 70.0 100.0 100.0 94.7 93.3 100.0
    91.1-100.0 61.9-68.4 63.8-70.0 90.4-100.0 92.3-100.0 89.1-94.7 86.2-93.3 94.0-100.0
Season           
Rainy 398 76.4 100.0 35.1 83.3 100.0 99.7 85.1 95.6 98.8
    98.7-100.0 30.8-35.1 82.2-83.3 87.6-100.0 98.2-100.0 80.5-86.1 94.2-95.9 93.4-99.9
Post-rainy 151 36.4 100.0 46.9 51.9 100.0 100.0 87.5 82.1 100.0
    92.7-100.0 42.7-46.9 48.1-51.9 91.1-100.0 93.2-100.0 83.6-87.5 76.5-82.1 95.5-100.0
Hot dry 145 11.7 100.0 78.9 38.6 100.0 100.0 97.7 85.0 100.0
    78.7-100.0 76.1-78.9 30.4-38.6 96.4-100.0 81.7-100.0 95.2-97.7 69.5-85.0 97.5-100.0
  1. Pf = P. falciparum, Pf HRP2 = P. falciparum Histidine-rich protein-2, Pf-pLDH = P. falciparum- specific parasite lactate dehydrogenase, pos = positive, SE = sensitivity, Sp = specificity, PPV = positive predictive value, NPV = negative predictive value.