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Figure 3 | Malaria Journal

Figure 3

From: Effects of the vascular endothelial growth factor receptor-2 (VEGFR-2) inhibitor SU5416 on in vitro cultures of Plasmodium falciparum

Figure 3

Intracellular VEGF content in parasitized red blood cells (PRBCs) is not affected by inhibiting VEGF, VEGFR-2, VEGFR-1, or tyrosine kinases. Median fluorescence intensity of PRBCs collected at day 3 from cultures of P. falciparum after staining for intracellular VEGF, determined by flow cytometry. Neither inhibition of VEGF by bevacizumab (A), nor specific inhibition of VEGFR-2 by SU5416 (B), or VEGFR-1 by anti-VEGFR-1 peptide (C) significantly altered the accumulation of VEGF in PRBCs. Broad inhibition of tyrosine kinases by adding genistein (D) had no effect on accumulation of VEGF in PRBCs.

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