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Table 1 Ex vivo susceptibility of Plasmodium falciparum isolates against chloroquine, monodeshethylamodiaquine, quinine, lumefantrine and dihydroartemisinin

From: Ex vivo anti-malarial drugs sensitivity profile of Plasmodium falciparum field isolates from Burkina Faso five years after the national policy change

  Culture success rate % (n/N) IC50 mean (nM) [95% CI] Range (nM) Resistant isolates (%)
Minimum Maximum
Chloroquine 86.8 (382/440) 69.2 [60.6 – 79.1] 8.3 595.9 161 (42.1)
Quinine 86.8 (382/440) 162.1 [148.3 – 177.3] 10.2 950.3 4 (1.0)
Monodesethylamodiaquine 85.7 (377/440) 19.3 [18.0 – 20.6] 0.8 595.9 24 (6.4)
Lumefantrine 86.8 (382/440) 25.1 [22.4 – 28.2] 0.8 166.1 NA
Piperaquine 79.3 (349/440) 6.3 [5.9 – 6.8] 0.8 375.2 NA
Dihydroartemisinin 86.5 (381/440) 0.8 [0.8 – 0.9] 0.1 38.8 NA
  1. Resistance threshold defined for chloroquine at 100 nM, quinine at 800 nM and monodeshethylamodiaquine at 60 nM; NA: Non applicable as the threshold is not defined yet.