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Figure 2 | Malaria Journal

Figure 2

From: Auto-induction of phase I and phase II metabolism of artemisinin in healthy Chinese subjects after oral administration of a new artemisinin-piperaquine fixed combination

Figure 2

Representative full-scan chromatograms of (A) a blank human plasma sample spiked with IS (ARM, 1 μM); (B) a blank human plasma sample spiked with artemisinin (QHS; 17.7 nM), deoxyartemisinin (Deoxy-QHS; 18.8 nM), and IS (ARM, 1 μM); and (C) a human plasma sample at 1.25 h after a single oral dose of QHS (1.8 mg/kg). I: QHS and monohydroxylated deoxyartemisinin (m/z 283.1540); II: deoxyartemisinin (deoxy-QHS; m/z 284.1856); III: monohydroxylated artemisinin (m/z 316.1775); IV: dihydroxylated artemisinin (m/z 332.1704) V: the glucuronide of monohydroxylated deoxy-QHS M5 (m/z 476.2126); VI: the glucuronide of monohydroxylated QHS (m/z 492.2076); VII: IS (ARM, m/z 316.2118).

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Malaria Journal

ISSN: 1475-2875

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