Figure 2
From: Using infective mosquitoes to challenge monkeys with Plasmodium knowlesi in malaria vaccine studies
Effect of number of infected mosquitoes feeding on day parasites detected in blood. Thirty monkeys were infected with P. knowlesi by the bite of from 1 to 10 mosquitoes which had sporozoites in the salivary glands and had ingested blood. The day on which the first P. knowlesi parasites were found in the blood is plotted against the number of infectious bites. Increasing numbers of bites lead to earlier detection of parasites in the blood. Cox regression analysis shows the number of infected mosquito bites increased the hazard of parasites appearing in the blood (p = 0.01).