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Table 4 Results of a mosquito bite challenge in 17 rhesus monkeys

From: Using infective mosquitoes to challenge monkeys with Plasmodium knowlesi in malaria vaccine studies

Monkey ID

Vaccine

# Mosquitoes with both sporozoites and ingested blood

Sporozoite grade of blood feeding mosquitoes

Day 1stparasite seen in blood

1

Control

2

4,4

9

2

Control

3

4,4,4

8

3

Control

3

4,4,4

8

4

Control

4

4,4,4,4

8

5

Control

4

4,4,4,4

7

6

Control

4

2,4,4,4

9

7

Vaccine

2

4,4

7

8

Vaccine

3

4,4,4

7

9

Vaccine

3

4,4,4

9

10

Vaccine

3

2,4,4

8

11

Vaccine

4

2,3,4,4

8

12

Vaccine

4

4,4,4,4

9

13

Vaccine

4

4,4,4,4

7

14

Vaccine

4

3,4,4,4

7

15

Vaccine

5

4,4,4,4,4

9

16

Vaccine

5

2,4,4,4,4

7

17

Vaccine

5

4,4,4,4,4

7

  1. 17 rhesus monkeys were exposed to five P. knowlesi infected mosquitoes for 15 minutes, in two groups of 8 and 9 monkeys each. The six control monkeys and 11 monkeys receiving malaria vaccine were challenged in random order, but are shown by group for ease of analysis. Mosquitoes were dissected to determine sporozoite grade in the salivary glands and the presence of ingested blood. All 17 monkeys developed parasites in the blood, and the first day parasites were detected is recorded.