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Table 2 Results of dhfr and dhps genotyping from all day 0 specimens that had complete genotyping available (N = 84)

From: Efficacy of sulphadoxine-pyrimethamine for intermittent preventive treatment of malaria in pregnancy, Mansa, Zambia

n dhfr mutations dhps mutations SP-IPTp efficacy outcome
51 59 108 437 540 581 APR* F†(R‡)
0 N/A N/A N/A
1 + 0 0 1
1 + + 0 0 1
6 + + + + 2 2 (1) 2
1 + + 1 0 0
1 + + + 0 0 1
1 + + + + 1 0 0
17 + + + 11 1 5
2 + + + + 1 0 1
1 + + + + 0 1 (1) 0
51 + + + + + 16 9 (4) 26
2 + + + + + + 2 0 0
  1. + = either mutant or mixed genotype.
  2. – = wildtype.
  3. *APR = adequate parasitological response.
  4. †F = parasitological failure.
  5. ‡R = reinfection (Only 14/15 patients with failure had specimens available for PCR. One patient with reinfection did not have a complete genotype available).
  6. §U = no outcome available (lost to follow-up or missing day 0 slide).