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Table 2 Results of dhfr and dhps genotyping from all day 0 specimens that had complete genotyping available (N = 84)

From: Efficacy of sulphadoxine-pyrimethamine for intermittent preventive treatment of malaria in pregnancy, Mansa, Zambia

n

dhfr mutations

dhps mutations

SP-IPTp efficacy outcome

51

59

108

437

540

581

APR*

F†(R‡)

U§

0

–

–

–

–

–

–

N/A

N/A

N/A

1

–

–

+

–

–

–

0

0

1

1

–

+

+

–

–

–

0

0

1

6

–

+

+

+

+

–

2

2 (1)

2

1

+

–

+

–

–

–

1

0

0

1

+

–

+

+

–

–

0

0

1

1

+

–

+

+

+

–

1

0

0

17

+

+

+

–

–

–

11

1

5

2

+

+

+

–

+

–

1

0

1

1

+

+

+

+

–

–

0

1 (1)

0

51

+

+

+

+

+

–

16

9 (4)

26

2

+

+

+

+

+

+

2

0

0

  1. + = either mutant or mixed genotype.
  2. – = wildtype.
  3. *APR = adequate parasitological response.
  4. †F = parasitological failure.
  5. ‡R = reinfection (Only 14/15 patients with failure had specimens available for PCR. One patient with reinfection did not have a complete genotype available).
  6. §U = no outcome available (lost to follow-up or missing day 0 slide).