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Table 2 In vitro sensitivity of Plasmodium falciparum isolates collected during 2006–2007 and 2008–2009 to chloroquine (CQ), quinine (QN), mefloquine (MQ), and artesunate (AS) and their sensitivity classification

From: Four years’ monitoring of in vitro sensitivity and candidate molecular markers of resistance of Plasmodium falciparum to artesunate-mefloquine combination in the Thai-Myanmar border

Drug Sensitivity classification Year 2006–2007 Year 2008–2009
% (n) IC50, nM % (n) IC50, nM
AS All 100 (56) 2.0 (1.5–2.4) 100 (63) 2.0 (1.5–2.5)
Sensitive 60.7 (34) 1.4 (1.3–1.6) 58.7 (37) 1.4 (1.1–1.8)
Declined sensitivity 39.3 (22) 3.1 (2.8–3.3) 41.3 (26) 3.7 (3.2–4.2)
MQ All 100 (56) 30.4 (18.0–42.7) 100 (63) 28.8 (16.7–41.0)
Sensitive 42.9 (24) 13.8 (11.3–16.3) 41.3 (26) 16.2 (13.2–19.2)
Resistant 57.1 (32) 51.5 (40.3–62.7) 58.3 (37) 58.7 (49.3–68.1)
CQ All 100 (56) 69.9 (62.8–77.1) 100 (63) 72.3 (65.4–79.2)
Sensitive 1.8 (1) 9.6
Moderate resistant 76.8 (43) 65.9 (59.9–72.0) 69.8 (44) 66.6 (62.3–70.8)
Highly resistant 21.4 (12) 124.3 (108.1–140.6) 30.2 (19) 132.3 (68.1–196.5)
QN All 100 (56) 236.3 (186.2–286.4) 100 (63) 230.5 (164.8–296.2)
Sensitive 78.6 (44) 223.0 (178.6–267.3) 93.7 (59) 214.9 (150.4–279.4)
Resistant 21.4 (12) 648.9 (606.1–691.6) 6.3 (4)** 593.6 (491.0–696.2)
  1. Data presented as median IC50 (95% CI) and percentage (number).
  2. **Significant lower proportion than isolates collected from 2006–2007 (p = 0.016, Chi–square test).