Skip to main content

Table 1 Minor allele frequencies and test of Hardy-Weinberg equilibrium in selected candidate SNPs

From: Association of candidate gene polymorphisms and TGF-beta/IL-10 levels with malaria in three regions of Cameroon: a case–control study

Gene Alternate SNP name SNP Location Minor allele frequency HWE
Maj/Min Cases (n = 971) Controls (n = 891) (P value)
HBB HbS rs334 Genic A/T 0.054 0.088 0.189
GBP7   rs1803632 P C/G 0.474 0.497 0.074
DARC   rs2814778 UTR A/G 0.006 0.003 1.000
CR1   rs17047660 UTR A/G 0.283 0.301 0.409
CR1   rs17047661 Genic G/A 0.277 0.272 0.379
C6   rs1801033 Genic A/C 0.415 0.417 0.515
CTL4   rs2242665 Genic A/G 0.319 0.324 0.642
NOD1   rs2075820 P G/A 0.401 0.397 0.170
CD36   rs3211938 Genic T/G 0.144 0.148 0.409
CFTR   rs17140229 Genic C/T 0.401 0.408 0.129
ABO   rs8176746 Genic C/A 0.166 0.170 0.173
TRIM5   rs7935564 Genic G/A 0.486 0.486 0.273
RTN3   rs542998 Genic C/T 0.379 0.384 0.375
SPTB   rs229587 Genic T/C 0.290 0.291 0.669
ADCY9   rs2230739 Genic A/G 0.092 0.104 0.434
ADCY9   rs10775349 Genic C/G 0.151 0.169 0.462
ADORA2B   rs2535611 Genic T/C 0.099 0.110 0.715
NOS2   rs2297518 Genic G/A 0.105 0.139 0.552
NOS2 NOS2-954 rs1800482 UTR G/C 0.082 0.080 0.812
NOS2   rs9282799 UTR C/T 0.040 0.036 0.076
NOS2 NOS2-1659 rs8078340 UTR C/T 0.270 0.280 0.200
EMR1   rs373533 Genic G/T 0.444 0.463 0.942
EMR1   rs461645 Genic C/T 0.446 0.468 1.000
ICAM1 ICAM-1codon469 rs5498 Genic A/G 0.119 0.141 0.238
GNAS GNAS_8386 rs8386 Genic C/T 0.159 0.154 0.224
DERL3   rs1128127 Genic A/G 0.464 0.457 0.481
CD40LG(F)   rs3092945 P T/C 0.295 0.269 0.359
CD40LG(M)   rs3092945 P T/C 0.295 0.257 < 0.001
CD40LG(F)   rs1126535 Genic T/C 0.188 0.161 0.190
CD40LG(M)   rs1126535 Genic T/C 0.159 0.216 < 0.001
G6PD(F)   rs1050829 P T/C 0.360 0.333 0.342
G6PD(M)   rs1050829 P T/C 0.360 0.341 < 0.001
G6PD(F)   rs1050828 P C/T 0.031 0.089 0.711
G6PD(M)   rs1050828 P C/T 0.120 0.106 < 0.001
  1. UTR 3’untranslated region, P promoter, Maj/Min = Major/Minor allele, M = male, F = Female One degree of freedom χ 2 test of HWE applied to the 891 controls.