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Table 1 Transmission-blocking activities of human polyclonal IgGs fed with infected blood meal a

From: Effect of ingested human antibodies induced by RTS, S/AS01 malaria vaccination in children on Plasmodium falciparum oocyst formation and sporogony in mosquitoes

Sample

Mean oocb

PIm[o]c

p-valued

Mosquitoe

PIp[o]f

p-valueg

Mean Spzh

PIm[s]i

p-valuej

CS-1

10.7

4

0.87

1/20

-9

0.36

14.8

-51

0.32

 

(0, 34)

(-142, 64)

  

(-30, 14)

 

(0, 52.3)

(-257, 31)

 

CS-2

10.8

3

0.88

1/20

-9

0.36

15.3

-56

0.29

 

(0, 20)

(-134, 65)

  

(-30, 14)

 

(0, 43.0)

(-274, 30)

 

CS-3

12.2

-9

0.95

1/20

-9

0.36

10.1

-3

0.94

 

(0, 38)

(-174, 59)

  

(-30, 14)

 

(0, 19.3)

(-152, 54)

 

CS-4

14.2

-27

0.67

1/20

-9

0.36

9.1

6

0.89

 

(0, 26)

(-208, 53)

  

(-30, 14)

 

(0, 41.3)

(-150, 61)

 

Contl-1

10.6

N/A

N/A

2/20

N/A

N/A

8.9

N/A

N/A

 

(0, 49)

     

(0, 22.8)

  

Contl-2

11.7

N/A

N/A

3/20

N/A

N/A

10.6

N/A

N/A

 

(0, 34)

     

(0, 25.3)

  
  1. aAll purified IgGs were tested at 3.75 mg/ml and fed with infected blood meal at the same time.
  2. bArithmetic mean (range) of oocysts per mosquito midgut.
  3. cPer cent inhibition of mean oocyst intensity (PIm[o]) and the 95% confidence interval (95% CI).
  4. dTwo-sided p-values for testing whether PIm[o] is significantly different from 0.
  5. eNumber of mosquitoes without any oocysts/number of mosquitoes examined.
  6. fPer cent inhibition of prevalence of mosquitoes with oocysts (PIp[o]) and the 95% CI.
  7. gp-values of PIp[o].
  8. hArithmetic mean (range) of sporozoites (×103) per mosquito.
  9. iPer cent inhibition of mean sporozoite intensity (PIm[s]) and the 95% CI.
  10. jp-values of PIm[s].