Effect of ingested human antibodies induced by RTS, S/AS01 malaria vaccination in children on Plasmodium falciparum oocyst formation and sporogony in mosquitoes

Table 4 Transmission-blocking activities of human mAb fed with infected blood meal ^a

Sample	Mean ooc^b	PIm[o]^c	p-value^d	Mosquito^e	PIp[o]^f	p-value^g	Mean Spz^h	PIm[s]ⁱ	p-value^j
First experiment
MAL1C	18.8	3	0.94	3/20	11	0.29	37.9	-21	0.72
	(0, 55)	(-191, 67)			(-14, 33)		(0, 94.0)	(-254, 58)
MAL2A	7.5	61	0.09	7/20	32	0.02	39.0	-24	0.63
	(0, 37)	(-24, 87)			(7, 55)		(0.5, 89.0)	(-215, 51)
Contl	19.5	N/A	N/A	1/20	N/A	N/A	31.2	N/A	N/A
	(0, 36)						(0, 146.5)
Second experiment
MAL1C	33.8	-21	0.71	0/20	0	1.000	N.D.	N.D.	N.D.
	(12, 59)	(-248, 56)			(-19, 16)
MAL2A	42.2	-51	0.46	0/20	0	1.000	N.D.	N.D.	N.D.
	(13, 71)	(-344, 49)			(-19, 16)
Contl	27.9	N/A	N/A	0/20	N/A	N/A	N.D.	N.D.	N.D.
	(1, 55)

^aAll mAb were tested at 0.231 mg/ml and fed with infected blood meal at the same time.
^bArithmetic mean (range) of oocysts per mosquito midgut.
^cPer cent inhibition of mean oocyst intensity (PIm[o]) and the 95% confidence interval (95% CI).
^dTwo-sided p-values for testing whether PIm[o] is significantly different from 0.
^eNumber of mosquitoes without any oocysts/number of mosquitoes examined.
^fPer cent inhibition of prevalence of mosquitoes with oocysts (PIp[o]) and the 95% CI.
^gp-values of PIp[o].
^hArithmetic mean (range) of sporozoites (×10³) per mosquito. No sporozoite count in the second experiment.
ⁱPer cent inhibition of mean sporozoite intensity (PIm[s]) and the 95% CI.
^jp-values of PIm[s].

ISSN: 1475-2875