Effect of ingested human antibodies induced by RTS, S/AS01 malaria vaccination in children on Plasmodium falciparum oocyst formation and sporogony in mosquitoes

Table 5 Transmission-blocking activities of human mAb fed three days post-infected blood meal ^a

Sample	Mean ooc^b	PIm[o]^c	p-value^d	Mosquito^e	PIp[o]^f	p-value^g	Mean Spz^h	PIm[s]ⁱ
MAL1C	15.1	2	0.97	1/20	-27	0.08	9.0	53
	(0, 36)	(-185, 65)			(-80, 3)
MAL2A	11.6	24	0.64	1/20	-27	0.08	19.8	-4
	(0, 30)	(-119, 74)			(-80, 3)
Contl	15.3	N/A	N/A	5/20	N/A	N/A	19.0	N/A
	(0, 44)

^aAll mAb were tested at 0.231 mg/ml and fed three days post-infected blood meal.
^bArithmetic mean (range) of oocysts per mosquito midgut.
^cPer cent inhibition of mean oocyst intensity (PIm[o]) and the 95% confidence interval (95% CI).
^dTwo-sided p-values for testing whether PIm[o] is significantly different from 0.
^eNumber of mosquitoes without any oocysts/number of mosquitoes examined.
^fPer cent inhibition of prevalence of mosquitoes with oocysts (PIp[o]) and the 95% CI.
^gp-values of PIp[o].
^hNumber of sporozoites (×10³) per mosquito calculated from a pool of salivary glands of 12 mosquitoes.
ⁱPer cent inhibition of mean sporozoite intensity (PIm[s]).

ISSN: 1475-2875