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Table 6 Transmission-blocking activities of human mAb fed six days post-infected blood meal a

From: Effect of ingested human antibodies induced by RTS, S/AS01 malaria vaccination in children on Plasmodium falciparum oocyst formation and sporogony in mosquitoes

Sample

Mean oocb

PIm[o]c

p-valued

Mosquitoe

PIp[o]f

p-valueg

Mean Spzh

PIm[s]i

MAL1C

48.5

-49

0.44

2/20

10

0.15

50.3

-129

 

(0, 88)

(-331, 49)

  

(-8, 30)

   

MAL2A

42.1

-29

0.61

0/20

0

1.00

23.3

-6

 

(20, 82)

(-287, 54)

  

(-19, 16)

   

Contl

32.6

N/A

N/A

0/20

N/A

N/A

22.0

N/A

 

(11, 64)

       
  1. aAll mAb were tested at 0.231 mg/ml and fed six days post-infected blood meal.
  2. bArithmetic mean (range) of oocysts per mosquito midgut.
  3. cPer cent inhibition of mean oocyst intensity (PIm[o]) and the 95% confidence interval (95% CI).
  4. dTwo-sided p-values for testing whether PIm[o] is significantly different from 0.
  5. eNumber of mosquitoes without any oocysts/number of mosquitoes examined.
  6. fPer cent inhibition of prevalence of mosquitoes with oocysts (PIp[o]) and the 95% CI.
  7. gp-values of PIp[o].
  8. hNumber of sporozoites (×103) per mosquito calculated from a pool of salivary glands of 12 mosquitoes.
  9. i Per cent inhibition of mean sporozoite intensity (PIm[s]).