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Table 1 Study characteristics

From: Glucose-6-phosphate dehydrogenase polymorphisms and susceptibility to mild malaria in Dogon and Fulani, Mali

  Dogon Fulani  
(n = 375, 52.7%) (n = 337, 47.3%) P-value
N (median) % (range) N (median) % (range)
Baseline characteristics
Age in months (192) (24 – 744) (168) (24 – 900) 0.25
Age groups (years)      0.31
 0-4 50 13.3 50 14.8  
 5-9 63 16.8 60 17.8  
 10-15 70 18.7 77 22.8  
 >15 192 51.2 150 44.5  
Male 174 46.4 160 47.5 0.84
Wet Season 298 79.5 259 76.9 0.45
Genetics      
Blood Group      0.003*
 O 161 44.7 183 55.6  
 B 108 30.0 62 18.8  
 AB 22 6.1 15 4.6  
 A 69 19.2 69 21.0  
HbS      0.62*
 AA genotype 358 97.0 327 97.9  
 AS genotype 11 3.0 7 2.1  
HbC      < 10-4
 AA genotype 339 92.4 332 99.1  
 AC/CC genotypes 28 7.6 3 0.9  
G6PD202A 29 7.7 2 0.6 < 10-4
G6PD376G 130 35.3 109 35.8 0.80
G6PD542A 375 100 337 100 -
G6PD680G 375 100 337 100 -
G6PD968T 375 100 316 93.9 -
Clinical phenotypes
Malaria      0.01*
 Clinical 61 16.3 30 8.9  
 Asymptomatic 77 20.5 73 21.7  
 No malaria 237 63.2 234 69.4  
Hyperparasitaemia 55 14.7 25 7.4 0.003
Parasite positivity 105 28.5 71 21.3 0.03
Spleen enlargement 34 9.1 116 34.4 < 10-6
Immunological pheno.
AMA1 (1269) (0 – 72,770) (1684) (3 – 72,770) 0.125
MSP1 (542) (0 – 131,800) (2099) (19 – 356,900) < 10-6
MSP2 (1735) (0 – 777,500) (4396) (49 – 777,500) < 10-6
CSP (747) (75 – 779,700) (1331) (0 – 1,387,000) 0.0002
Total IgE (1432) (0 – 21,780) (1702) (171 – 28,960) 0.008
  1. *p-value for an overall effect.