Table 1 Admission demographic, clinical and laboratory details for patients included in the study on thiamin treatment and Plasmodium falciparum malaria in Laos
Variables | Treatment groups | ||
|---|---|---|---|
All (N = 630) | Thiamin (n = 314) | Placebo (n = 316) | |
Sex, M, no (%) | 317 (50) | 155 (49) | 162 (51) |
Age, years, median (range) | 8 (0.5 – 73) | 9 (0.5 – 63) | 8 (0.7 – 73) |
No. (%) patients aged <15 years | 414 (66) | 204 (65) | 210 (66) |
Body weight, kg | 28.1 (26.8 – 29.4) | 28.7 (26.8 – 30.7) | 27.5 (25.6 – 29.3) |
Height, cm | 122.1 (119.9 – 124.4) | 122.8 (119.5 – 126.0) | 121.5 (118.5 – 124.8) |
Previous malaria attack, no. (%) of patientsa | 166 (26) | 85 (27) | 81 (26) |
Axillary temperature, °C | 38.4 (38.3 – 38.5) | 38.4 (38.3 – 38.5) | 38.5 (38.3 – 38.6) |
Patients without fever on admission, no. (%) | 159 (25) | 85 (27) | 74 (23) |
Systolic blood pressure, mm Hg | 100.8 (99.8 – 101.9) | 100.7 (99.2 – 102.2) | 100.9 (99.4 – 102.4) |
Diastolic blood pressure, mm Hg | 68.8 (68.0 – 69.7) | 68.9 (67.6 – 70.1) | 68.8 (67.7 – 70.0) |
Pulse, beats/min | 96.4 (95.2 – 97.5) | 96.0 (94.4 – 97.6) | 96.7 (95.2 – 98.3) |
Respiratory rate/min | 28.1 (27.6 – 28.6) | 27.8 (27.1 – 28.6) | 28.4 (27.7 – 29.1) |
Glasgow coma score, median (range) | 15 (4 – 15) | 15 (12 – 15) | 15 (4 – 15) |
Severe malaria, no. (%) [WHO, 2000] | 34 (5) | 18 (6) | 16 (5) |
Pregnancy, no. (%) | 29 (5) | 13 (4) | 16 (5) |
Headache visual analogue score* | 5.2 (5.0 – 5.5) | 5.3 (5.0 – 5.7) | 5.1 (4.7 – 5.7) |
Dizziness visual analogue score, median (range)* | 4 (0 – 10) | 4 (0 – 10) | 4 (0 – 10) |
Splenomegaly, no. (%) of patients | 163/628 (26) | 85/313 (27) | 78/315 (25) |
Hepatomegaly, no (%) of patients | 143/627 (23) | 63/313 (20) | 80/314 (25) |
Lymphadenopathy, no (%) of patients | 2/629 (0.3%) | 1/313 (0.3%) | 1/316 (0.3) |
Parasitaemia, geometric mean parasites/μL (95%CI) | 25,677 (22,350 – 29,499) | 27,775 (22,995 – 33,549) | 23,750 (19,369 – 29,123) |
Mixed malaria species infection, no. (%) | 11 (2) | 5 (2) | 6 (2) |
Gametocytaemia, no. (%) of patients | 27 (4) | 14 (4) | 13 (4) |
Gametocytaemia, geometric mean parasite/μL (95%CI) | 255 (125 – 521) | 198 (78 – 503) | 334 (98 – 1,134) |
Haematocrit, % | 35.6 (35.0 – 36.1) | 35.6 (34.8 – 36.4) | 35.5 (34.7 – 36.3) |
Glucose, mmol/L | 6.1 (6.0 – 6.2) | 6.2 (6.1 – 6.3) | 6.0 (5.9 – 6.2) |
Lactate, mmol/L | 3.2 (3.1 – 3.3) | 3.1 (3.0 – 3.2) | 3.3 (3.1 – 3.4) |