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Table 2 Admission symptoms and signs for patients included in the study on thiamin treatment and Plasmodium falciparum malaria in Laos

From: Thiamin supplementation does not reduce the frequency of adverse events after anti-malarial therapy among patients with falciparum malaria in southern Laos

Symptoms and signs

All (N = 630)

Treatment groups

  

Thiamin (n = 314)

Placebo (n = 316)

P-value

Headache*

403/439 (92)

203/218 (93)

200/221 (90.5)

0.32

Headache visual analogue

5 (0 – 10)

5 (5 – 10)

5 (0 – 10)

0.60

score: median (range)*

    

Chill

569/630 (90)

281/314 (89)

288/316 (91)

0.48

Myalgia*

246/438 (56)

127/218 (58)

119/220 (54)

0.38

Weakness

600/629 (95)

297/313 (95)

303/316 (96)

0.55

Dizziness*

324/438 (74)

162/218 (74)

162/220 (74)

0.87

Dizziness visual analogue

4 (0 – 10)

4 (0 – 10)

4 (0 – 10)

0.98

score: median (range)*

    

Vertigo*

124/438 (28)

62/218 (28)

62/220 (28)

0.95

Tinnitus*

93/438 (21)

54/218 (25)

39/220 (18)

0.07

Anorexia

567/630 (90)

284/314 (90)

283/316 (90)

0.71

Nausea*

295/440 (67)

146/219 (67)

149/221 (67)

0.87

Vomiting

343/630 (54)

171/314 (54)

172/316 (54)

0.99

Abdominal pain*

123/448 (27)

64/220 (29)

59/228 (26)

0.44

Diarrhoea

130/629 (21)

74/314 (24)

56/315 (18)

0.07

Insomnia*

372/630 (59)

185/314 (59)

187/316 (59)

0.98

Nightmare*

40/438 (9)

19/218 (9)

21/220 (10)

0.76

Palpitation*

186/439 (42)

95/219 (43)

91/220 (41)

0.67

Dyspnoea*

160/627 (25.5)

71/312 (23)

89/315 (28)

0.11

Cough

142/630 (22)

60/314 (19)

82/316 (26)

0.04

Sore throat*

55/447 (12)

24/222 (11)

31/225 (14)

0.34

Irritable

22/628 (3.5)

9/313 (3)

13/315 (4)

0.39

Rash

1/630 (0.2)

1/314 (0.3)

0

0.31

Urticaria

4/630 (0.6)

2/314 (0.6)

2/316 (0.6)

0.99

Itch

4/630 (0.6)

1/314 (0.3)

3/316 (1)

0.32

Chest abnormality**

2/630 (0.3)

0

2/316 (0.6)

0.16

Drowsiness

19/630 (3)

10/314 (3)

9/316 (3)

0.80

Seizure

21/630 (3)

12/314 (4)

9/316 (3)

0.49

Jaundice

1/630 (0.2)

1/314 (0.3)

0

0.31

  1. NOTE. Data are shown as number (%) unless otherwise indicated, *Only children aged ≥ 4 years were asked about these symptoms, **Chest abnormality: crepitation, rhonchi.