Figure 2

Haplotype influence on inflammatory mediators and outcomes of malaria infection. Each symbol represents a single patient, and the lines represent medians and interquartile range. (A) The figure represents all the possible haplotypes for TNF-308G > A, DDX39B-348C > T, and DDX39B-22C > G polymorphisms. Haplotypes were compared between the 3 categories of vivax malaria infections (uninfected, asymptomatic, mild malaria). (B) CRP levels in participants with GGC haplotype compared to individuals with other haplotypes. (C) CXCL10 plasma concentration in participants with GCC haplotype compared to individuals with other haplotypes. (D) TNF levels in participants with different haplotypes. Each haplotype was compared with participants with other haplotypes. The differences between groups illustrated in (A) were compared using the chi-square test. The data in (B), (C), and (D) were compared using the Mann–Whitney test. P values are shown in each panel.