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Table 5 DDX39B polymorphisms (-22C > G and -348C > T) and complicated vivax malaria infections: second series of participants from Amazonas, Brazil

From: DDX39B (BAT1), TNF and IL6 gene polymorphisms and association with clinical outcomes of patients with Plasmodium vivax malaria

  Genotype χ2 Allele frequency χ2 CC vs CG + GG χ2
  CC n (%) CG n (%) GG n (%) C (%) G (%)
DDX39B-22 polymorphism         
Mild malaria (n = 69) 5 (7.25) 41 (59.42) 23 (33.33) 6.72 p = 0.0347 51 (36.96) 87 (63.04) p = 0.0628* p = 0.0207*
Complicated malaria (n = 31) 8 (25.80) 16 (51.61) 7 (22.58) 32 (51.61) 30 (48.39)
  Genotype   Allele frequency   CC vs TC + TT χ2
  CC n (%) TC n (%) TT n (%)   C (%) T (%)  
DDX39B-348 polymorphism         
Mild malaria (n = 69) 55 (79.71) 14 (20.29) 0 (0.00) p = 7,850*# 124 (89.86) 14 (10.14) p = 0.7965* p = 7,850*
Complicated malaria (n = 31) 26 (83.87) 5 (16.13) 0 (0.00) 57 (91.93) 5 (8.07)
  1. *In these cases, Fisher exact test was used. #Analysis excluded genotype TT. χ2: coefficient and P value measured using Chi-square test.