DDX39B (BAT1), TNF and IL6 gene polymorphisms and association with clinical outcomes of patients with Plasmodium vivax malaria

Table 5 DDX39B polymorphisms (-22C > G and -348C > T) and complicated vivax malaria infections: second series of participants from Amazonas, Brazil

	Genotype			χ2	Allele frequency		χ2	CC vs CG + GG χ2
	CC n (%)	CG n (%)	GG n (%)	χ2	C (%)	G (%)	χ2	CC vs CG + GG χ2
*DDX39B-22* polymorphism
Mild malaria (n = 69)	5 (7.25)	41 (59.42)	23 (33.33)	6.72 p = 0.0347	51 (36.96)	87 (63.04)	p = 0.0628*	p = 0.0207*
Complicated malaria (n = 31)	8 (25.80)	16 (51.61)	7 (22.58)	6.72 p = 0.0347	32 (51.61)	30 (48.39)	p = 0.0628*	p = 0.0207*
	Genotype				Allele frequency			CC vs TC + TT χ2
	CC n (%)	TC n (%)	TT n (%)		C (%)	T (%)		CC vs TC + TT χ2
*DDX39B-348* polymorphism
Mild malaria (n = 69)	55 (79.71)	14 (20.29)	0 (0.00)	p = 7,850*^#	124 (89.86)	14 (10.14)	p = 0.7965*	p = 7,850*
Complicated malaria (n = 31)	26 (83.87)	5 (16.13)	0 (0.00)	p = 7,850*^#	57 (91.93)	5 (8.07)	p = 0.7965*	p = 7,850*

*In these cases, Fisher exact test was used. ^#Analysis excluded genotype TT. χ2: coefficient and P value measured using Chi-square test.

ISSN: 1475-2875