Pharmacokinetic evaluation of intravenous artesunate in adults with uncomplicated falciparum malaria in Kenya: a phase II study

Table 2 The main pharmacokinetic parameters of artesunate (AS) and dihydroartemisinin (DHA) following intravenous (IV) administrations in malaria patients and volunteers

					Artesunate (AS)				Dihydroartemisinin (DHA)			Ratio of AUC_DHA/AS	Refs
Patients	Where	Cases	Date	Route	Dose	C_maxng/mL	AUC ng · h/mL	t_1/2 min	C_maxng/mL	AUC ng · h/mL	t_1/2 min	Ratio of AUC_DHA/AS	Refs
Children	Gabon	10	2002	IV	2.4 mg/kg	29,683	3,752	1.5	3,012	3,325	20.7	0.89	[22]
Children	Ghana	9	2001	IV	2.4 mg/kg				1,593	1,708	31.8	-	[23]
Adults	Vietnam	13	1998	IV	120 mg/person	11,343	1,146	2.7	2,646	2,378	40.2	2.08	[24]
Adults	Vietnam	11	2002	IV	120 mg/person	16,149	1,038	3.2	2,760	2,873	59.0	2.77	[25]
Adults	Thailand	2	2000	IV	2 mg/kg	-	1,056		-	3,999	-	3.79	[26]
Adults	Vietnam	12	1998	IV	120 mg/person	13,688	877	2.2	2,193	1,846	36.7	2.10	[2]
Volunteer	Vietnam	10	2001	IV	120 mg/person	-	846	2.6	1,508	1,365	53.0	1.61	[27]
Adults	Vietnam	8	2001	IV	120 mg/person	-	-	2.3	2,423	2,081	40.0	-	[3]
Adults	Vietnam	6	2001	IV	120 mg/person	-	-	4.3	2,537	2,565	64.1	-	[28]
Adults	Vietnam	10	2001	IV	240 mg/person	-	-	3.2	912	5,586	46.2	-	[27]
Adults	Thailand	17	2006	IV	2.4 mg/kg	130	49	13.2	605	418	20.4	8.53	[28]
Volunteer	USA	6	2009	IV	2 mg/kg	19,420	1,595	14.4	1,456	1,821	78.6	1.14	[15]
Volunteer	USA	6	2012	IV	2 mg/kg	28,411	2,051	9.6	1,735	2,121	104.4	1.03	[16]
Adults	Kenya	28	2014	IV	2.4 mg/kg	28,558	1,878	10.2	2,932	3,543	78.0	1.94	Present

The drug measurements are by using HPLC-ECD or LC-MS methods, and some drug evaluations by using bioassay are not selected in this summary.
PNG = Papua New Guinea.

ISSN: 1475-2875