Table 3 Risk of Plasmodium falciparum treatment failure among patients in studies of the National Antimalarial Drug Resistance Monitoring System, northeast India, 2012-2013
From: Declining efficacy of artesunate plus sulphadoxine-pyrimethamine in northeastern India
Predictor | Value | Faila | ACPR | Risk | RR | 95% CI |
|---|---|---|---|---|---|---|
Artesunate dose (mg/kg) | ≥ 3.5 | 24 | 84 | 0.222 | ||
3.0-3.5 | 5 | 21 | 0.192 | 0.64 | 0.19, 2.19 | |
< 3.0 | 3 | 7 | 0.300 | 1.35 | 0.49, 3.71 | |
Age | < 5 | 13 | 18 | 0.419 | 2.17 | 1.11, 2.46 |
(years) | 5-15 | 11 | 46 | 0.193 | 1.35 | 0.58, 3.11 |
≥ 15 | 8 | 48 | 0.143 | -- | ||
Parasite count | < 5000 | 6 | 38 | 0.136 | 0.65 | 0.28, 1.53 |
(/μL) | 5000 - 50000 | 17 | 64 | 0.210 | 0.44 | 0.23, 0.84 |
≥ 50000 | 9 | 10 | 0.474 | -- | ||
#Antifolate | Wild | 0 | 0 | 0.000 | -- | |
mutations | 1-2 | 0 | 6 | 0.000 | -- | |
3-4 | 5 | 11 | 0.313 | 1.48 | 0.65, 3.34 | |
5-6 | 22 | 82 | 0.212 | 0.68 | 0.29, 1.53 | |
7-8 | 5 | 11 | 0.313 | -- | ||
Fever | Yes | 25 | 73 | 0.255 | 1.68 | 0.78, 3.59 |
(≥ 37.5°C) | No | 7 | 39 | 0.152 | -- | |
Previous | Yes/unknown | 17 | 69 | 0.198 | 0.76 | 0.42, 1.41 |
Drug intake | No | 15 | 43 | 0.259 | -- |