Table 3 Performance of HRP-2 test in asymptomatic carriers by age and parasite density
Age group (years) | Parasite density (/μl) | N | Positive | Negative | Sensitivity % (95% CI) | Specificity % (95% CI) |
|---|---|---|---|---|---|---|
0- <5 | 0-99 | 2,663 | 433 | 2,230 | 74.6 (64.5, 84.8) | |
100-499 | 90 | 83 | 7 | 92.2 (86.7, 97.8) | ||
500-999 | 86 | 85 | 1 | 98.8 (96.6, 100) | ||
1,000-4,999 | 211 | 209 | 2 | 99.1 (97.7, 100) | ||
≥5,000 | 117 | 114 | 3 | 97.4 (94.6, 100) | ||
Overall | 3,167 | 924 | 2,243 | 94.6 (92.8, 96.5) | 85.3 (84.0, 86.7) | |
5-9 | 0-99 | 2,147 | 327 | 1,820 | 84.0 (75.7, 92.3) | |
100-499 | 184 | 171 | 13 | 92.9 (89.2, 96.6) | ||
500-999 | 145 | 143 | 2 | 98.6 (96.7, 100) | ||
1,000-4,999 | 246 | 245 | 1 | 99.6 (98.8, 100) | ||
≥5,000 | 69 | 68 | 1 | 98.6 (95.7, 100) | ||
Overall | 2,791 | 954 | 1,837 | 96.0 (94.5, 97.4) | 87.3 (85.8, 88.7) | |
10-14 | 0-99 | 2,124 | 346 | 1,778 | 85.5 (79.8, 91.2) | |
100-499 | 215 | 206 | 9 | 95.8 (93.1, 98.5) | ||
500-999 | 104 | 103 | 1 | 99.0 (97.2, 100) | ||
1,000-4,999 | 145 | 144 | 1 | 99.3 (98.0, 100) | ||
≥5,000 | 31 | 31 | 100 (100, 100) | |||
Overall | 2,619 | 830 | 1,789 | 95.0 (93.3, 96.7) | 88.8 (87.4, 90.2) | |
≥15 | 0-99 | 8,287 | 1,129 | 7,158 | 73.1 (68.8, 77.5) | |
100-499 | 310 | 265 | 45 | 85.5 (81.6, 89.4) | ||
500-999 | 107 | 101 | 6 | 94.4 (90.0, 98.8) | ||
1,000-4,999 | 66 | 64 | 2 | 97.0 (92.8, 100) | ||
≥5,000 | 17 | 10 | 7 | 58.8 (35.4, 82.2) | ||
Overall | 8,787 | 1,569 | 7,218 | 81.4 (78.8, 83.9) | 89.4 (88.7, 90.1) |