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Table 3 Performance of HRP-2 test in asymptomatic carriers by age and parasite density

From: Lessons learned from the use of HRP-2 based rapid diagnostic test in community-wide screening and treatment of asymptomatic carriers of Plasmodium falciparum in Burkina Faso

Age group (years) Parasite density (/μl) N Positive Negative Sensitivity % (95% CI) Specificity % (95% CI)
0- <5 0-99 2,663 433 2,230 74.6 (64.5, 84.8)  
  100-499 90 83 7 92.2 (86.7, 97.8)  
  500-999 86 85 1 98.8 (96.6, 100)  
  1,000-4,999 211 209 2 99.1 (97.7, 100)  
  ≥5,000 117 114 3 97.4 (94.6, 100)  
  Overall 3,167 924 2,243 94.6 (92.8, 96.5) 85.3 (84.0, 86.7)
5-9 0-99 2,147 327 1,820 84.0 (75.7, 92.3)  
  100-499 184 171 13 92.9 (89.2, 96.6)  
  500-999 145 143 2 98.6 (96.7, 100)  
  1,000-4,999 246 245 1 99.6 (98.8, 100)  
  ≥5,000 69 68 1 98.6 (95.7, 100)  
  Overall 2,791 954 1,837 96.0 (94.5, 97.4) 87.3 (85.8, 88.7)
10-14 0-99 2,124 346 1,778 85.5 (79.8, 91.2)  
  100-499 215 206 9 95.8 (93.1, 98.5)  
  500-999 104 103 1 99.0 (97.2, 100)  
  1,000-4,999 145 144 1 99.3 (98.0, 100)  
  ≥5,000 31 31   100 (100, 100)  
  Overall 2,619 830 1,789 95.0 (93.3, 96.7) 88.8 (87.4, 90.2)
≥15 0-99 8,287 1,129 7,158 73.1 (68.8, 77.5)  
  100-499 310 265 45 85.5 (81.6, 89.4)  
  500-999 107 101 6 94.4 (90.0, 98.8)  
  1,000-4,999 66 64 2 97.0 (92.8, 100)  
  ≥5,000 17 10 7 58.8 (35.4, 82.2)  
  Overall 8,787 1,569 7,218 81.4 (78.8, 83.9) 89.4 (88.7, 90.1)
  1. N = number of subjects for whom RDT and microscopy results were available.