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Table 1 Prevalence of Pfmdr1 haplotypes at codon N86Y, Y184F and D1246Y in Maputo, before and after the introduction of artemisinin-based combination therapy

From: Prevalence of pfmdr1 alleles associated with artemether-lumefantrine tolerance/resistance in Maputo before and after the implementation of artemisinin-based combination therapy

Codon

Haplotype

2003-2005*

2010-2012*

86/184 (49;293)

NF

10.2

24.3

 

YF

8.2

0.3

 

NY

12.2

59.4

 

YY

69.4

16.0

86/1246 (77;286)

ND

27.3

84.4

 

NY

1.3

0.3

 

YD

64.9

13.6

 

YY

6.5

1.7

184/1246 (53;330)

FY

0.0

0.0

 

FD

20.8

23.3

 

YY

7.5

2.4

 

YD

71.7

74.3

86/184/1246 (45;282)

NFD

11.1

24.8

 

NFY

0.0

0.0

 

NYY

2.2

0.4

 

NYD

11.1

59.2

 

YYY

4.4

1.8

 

YFD

8.9

0.4

 

YFY

0.0

0.0

 

YYD

62.2

13.5

  1. *Sample collection period. Numbers in brackets represent number of samples collectedduring the correspondent periods 2003–2005;2010–2012.
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Malaria Journal

ISSN: 1475-2875

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