Table 3 Distribution and logistic regression analysis of the cytokine (TNF, IFN-γ) genotypes and allele frequency in relation to severe (SM) compared with uncomplicated malaria (UM) and malaria free control (MFC)
From: IFN-gamma and TNF associated with severe falciparum malaria infection in Saudi pregnant women
Dependent variable | MFC | UM | SM | Hardy-Weinberg equilibrium test |
|---|---|---|---|---|
n = 60(%) | n = 62(%) | n = 64(%) | ||
TNF −863 C/A* | ||||
CC | 6 (6.5%) | 32 (34.8%) | 54 (58.7%) | 0.61 |
CA | 27 (47.4%) | 22 (38.6%) | 8 (14.0%) | |
AA | 27 (73%) | 8 (21.6%) | 2 (5.4%) | |
Alleles frequency‡ | ||||
C | 0.32 | 0.69 | 0.91 | 0.33 |
A | 0.62 | 0.31 | 0.09 | |
IFN-γ -1616 T/C¥ | ||||
TT | 2 (2.6%) | 24 (31.2%) | 51 (66.2%) | 0.57 |
CT | 35 (49.3%) | 26 (36.6%) | 10 (14.1%) | |
CC | 23 (60.5%) | 12 (31.6%) | 3 (7.9%) | |
Alleles frequency £ | ||||
T | 0.33 | 0.60 | 0.88 | 0.21 |
C | 0.67 | 0.40 | 0.12 |