Table 1 In vitro IC 50 values for limonoids from Carapa guianensis against Plasmodium falciparum and human fibroblasts
Plasmodium falciparum K1 | Human fibroblasts MRC-5 | ||||
|---|---|---|---|---|---|
Limonoids | MW | IC50(μM) | Result | IC50(μM) | SI |
6α-acetoxyazadiradione (1) | 524 | 15.4 | MA | >191 | >12 |
andirobin (2) | 492 | 15.3 | MA | >203 | >13 |
6α-acetoxygedunin (3) | 540 | 7.0 | MA | >185 | >26 |
7-deacetyl-7-oxogedunin (4) | 438 | 20.7 | I | 108 (87.2–134) | 5 |
6α-hydroxydeacetylgedunin (5) | 456 | 5.0 | A | >219 | >44 |
chloroquine diphosphate | 516 | 0.33 | A | ||
quinine sulfate | 783 | 0.30 | A | ||