Skip to main content

Advertisement

Table 1 In vitro IC 50 values for limonoids from Carapa guianensis against Plasmodium falciparum and human fibroblasts

From: In vitro and in vivo anti-malarial activity of limonoids isolated from the residual seed biomass from Carapa guianensis (andiroba) oil production

   Plasmodium falciparum K1 Human fibroblasts MRC-5
Limonoids MW IC50(μM) Result IC50(μM) SI
6α-acetoxyazadiradione (1) 524 15.4 MA >191 >12
andirobin (2) 492 15.3 MA >203 >13
6α-acetoxygedunin (3) 540 7.0 MA >185 >26
7-deacetyl-7-oxogedunin (4) 438 20.7 I 108 (87.2–134) 5
6α-hydroxydeacetylgedunin (5) 456 5.0 A >219 >44
chloroquine diphosphate 516 0.33 A   
quinine sulfate 783 0.30 A   
  1. Notes: IC50 ≤ 0.1 μM = highly active; 0.1 < IC50 ≤ 5 μM = active (A); 5 < IC50 ≤ 20 μM = moderately active (MA); IC50 > 20 μM = inactive (I). Selectivity index (SI) = IC50 (human fibroblasts)/IC50 (P. falciparum).