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Table 2 Response to anti-malarial therapy

From: Early parasite clearance following artemisinin-based combination therapy among Ugandan children with uncomplicated Plasmodium falciparum malaria

Characteristic Treatment arm p-value
AL (n = 416) DP (n = 354)  
Parasite persistence, n (%)    
  Positive blood smear day 1 269 (67.6%) 181 (52.2%) <0.001
  Positive blood smear day 2 23 (5.6%) 20 (5.7%) 0.92
  Positive blood smear day 3 0 1 (0.3%) N/A
Fever persistence, n (%)    
  Febrile* day 1 124 (30.0%) 65 (18.4%) 0.002
  Febrile* day 2 8 (1.9%) 11 (3.1%) 0.28
  Febrile* day 3 7 (1.7%) 7 (2.0%) 0.78
28-day WHO treatment outcome, n (%)    
  Lost to follow-up 16 (3.9%) 13 (3.7%)  
  Early treatment failure 0 1 (0.3%)  
  Late parasitological failure 137 (32.9%) 22 (6.2%) < 0.001
  Late clinical failure 74 (17.8%) 7 (2.0%)  
  Adequate clinical and parasitological response 189 (45.4%) 311 (87.9%)  
  1. *Subjective fever in the previous 24 hours or temperature ≥38.0°C (tympanic).