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Table 2 Response to anti-malarial therapy

From: Early parasite clearance following artemisinin-based combination therapy among Ugandan children with uncomplicated Plasmodium falciparum malaria

Characteristic

Treatment arm

p-value

AL (n = 416)

DP (n = 354)

 

Parasite persistence, n (%)

   

  Positive blood smear day 1

269 (67.6%)

181 (52.2%)

<0.001

  Positive blood smear day 2

23 (5.6%)

20 (5.7%)

0.92

  Positive blood smear day 3

0

1 (0.3%)

N/A

Fever persistence, n (%)

   

  Febrile* day 1

124 (30.0%)

65 (18.4%)

0.002

  Febrile* day 2

8 (1.9%)

11 (3.1%)

0.28

  Febrile* day 3

7 (1.7%)

7 (2.0%)

0.78

28-day WHO treatment outcome, n (%)

   

  Lost to follow-up

16 (3.9%)

13 (3.7%)

 

  Early treatment failure

0

1 (0.3%)

 

  Late parasitological failure

137 (32.9%)

22 (6.2%)

< 0.001

  Late clinical failure

74 (17.8%)

7 (2.0%)

 

  Adequate clinical and parasitological response

189 (45.4%)

311 (87.9%)

 
  1. *Subjective fever in the previous 24 hours or temperature ≥38.0°C (tympanic).