Table 4 Associations between variables of interest and a positive blood slide on day 2

Anti-malarial treatment

DP

5.7%

1.0 (reference)

-

Not included in final model

AL

5.6%

1.03 (0.55-1.95)

0.92

mg/kg dosing of anti-malarial

≥ median (DP)

5.8%

1.0 (reference)

-

Not included in final model

< median (DP)

5.6%

1.00 (0.41-2.43)

0.99

≥ median (AL)

4.0%

1.0 (reference)

-

< median (AL)

7.1%

1.74 (0.70-4.38)

0.23

Temperature °C

< 37.0

2.6%

1.0 (reference)

-

1.0 (reference)

-

37.0-37.9

5.9%

2.35 (0.98-5.59)

0.05

2.32 (1.01-5.31)

0.048

≥ 38.0

7.8%

3.09 (1.28-7.46)

0.01

Parasite density per μL

< 4,000

1.4%

1.0 (reference)

-

1.0 (reference)

-

4,000-20,000

1.3%

> 20,000

8.3%

5.79 (2.35-14.3)

<0.001

5.12 (2.12-12.37)

<0.001

Haemoglobin g/dL

≥ 10

5.4%

1.0 (reference)

-

Not included in final model

< 10

6.0%

1.06 (0.46-2.45)

0.89

HIV status

Negative

5.0%

1.0 (reference)

-

1.0 (reference)

-

Positive

19.4%

3.87 (1.85-8.12)

<0.001

3.69 (1.54-8.84)

0.003

Episode number

1-2

6.9%

1.0 (reference)

-

Not included in final model

3-4

5.1%

0.74 (0.37-1.48)

0.39

≥5

3.7%

0.50 (0.20-1.29)

0.15