In vitro antiplasmodial activity of cepharanthine

Malaria Journal

Table 1 IC ₅₀ of cepharanthine against four Plasmodium falciparum strains

Compound/strain	FCM29	W2	3D7	K1
Cepharanthine	3059 (12.3%)	927 (6.5%)	2276 (15.8%)	1803 (17.5%)
Chloroquine (CQ)	738 (7.2%)	572 (19.5%)	21.2 (13.7%)	164 (35.1%)
Mefloquine (MQ)	24.5 (10.1%)	26.5 (9.2%)	67.0 (5.9%)	14.3 (28.0%)
IC₅₀ ratio (Cepharanthine/CQ)	4.1	1.6	107	11.0
IC₅₀ ratio (Cepharanthine/MQ)	125	35.0	34.0	126
IC₅₀ ratio (CQ/MQ)	30.1	21.6	0.3	11.5

The first three rows are IC₅₀ (arithmetic mean in nM, RSD%) of three drugs on four Plasmodium falciparum strains. These values have been computed using triplicates (n = 3). The last three rows are the IC₅₀ ratio between every pair of the tested drugs.

ISSN: 1475-2875