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Table 4 Biological parameter changes during treatment

From: Efficacy and safety of artemether-lumefantrine and dihydroartemisinin-piperaquine in the treatment of uncomplicated Plasmodium falciparum malaria in Kenyan children aged less than five years: results of an open-label, randomized, single-centre study

Parameter

AL dispersible

DP paediatric

p-value*

 

N

Mean change (95% CI)

N

Mean change (95% CI)

Haemoglobin (g/dl)

178

1.6 (1.3 to 1.9)

185

1.7 (1.4 to 1.9)

0.134

White blood cells (X103/μL)

178

−0.8 (−1.5 to −0.1)

185

−0.5 (−1.0 to 0.3)

0.869

Platelets (X103/μL)

178

88.5 (74.1 to 102.8)

185

88.3 (76.2 to 102.8)

0.926

Red blood cells (X106/μL)

178

0.6 (0.4 to 0.8)

185

0.7 (0.6 to 0.9)

0.394

Neutrophils (%)

178

−14.4 (−17.2 to −11.6)

185

−16.6 (−19.4 to −13.9)

0.857

Lymphocytes (%)

178

14.4 (11.3 to 17.4)

185

18.8 (16.0 to 21.6)

0.081

Eosinophils (%)

178

−0.2 (−0.7 to 0.2)

185

-

-

Basophils (%)

177

−0.02 (−0.10 to 0.07)

185

−0.08 (−0.19 to 0.03)

0.309

Monocytes (%)

177

−0.4 (−0.89 to 0.06)

185

−0.78 (−1.54 to −0.02)

0.633

  1. CI = confidence interval.
  2. A negative value indicates a decrease in day 28 values, on average compared to baseline.
  3. *p-value from ANCOVA test of difference at day 28 between arms adjusting for baseline values.