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Table 4 Biological parameter changes during treatment

From: Efficacy and safety of artemether-lumefantrine and dihydroartemisinin-piperaquine in the treatment of uncomplicated Plasmodium falciparum malaria in Kenyan children aged less than five years: results of an open-label, randomized, single-centre study

Parameter AL dispersible DP paediatric p-value*
  N Mean change (95% CI) N Mean change (95% CI)
Haemoglobin (g/dl) 178 1.6 (1.3 to 1.9) 185 1.7 (1.4 to 1.9) 0.134
White blood cells (X103/μL) 178 −0.8 (−1.5 to −0.1) 185 −0.5 (−1.0 to 0.3) 0.869
Platelets (X103/μL) 178 88.5 (74.1 to 102.8) 185 88.3 (76.2 to 102.8) 0.926
Red blood cells (X106/μL) 178 0.6 (0.4 to 0.8) 185 0.7 (0.6 to 0.9) 0.394
Neutrophils (%) 178 −14.4 (−17.2 to −11.6) 185 −16.6 (−19.4 to −13.9) 0.857
Lymphocytes (%) 178 14.4 (11.3 to 17.4) 185 18.8 (16.0 to 21.6) 0.081
Eosinophils (%) 178 −0.2 (−0.7 to 0.2) 185 - -
Basophils (%) 177 −0.02 (−0.10 to 0.07) 185 −0.08 (−0.19 to 0.03) 0.309
Monocytes (%) 177 −0.4 (−0.89 to 0.06) 185 −0.78 (−1.54 to −0.02) 0.633
  1. CI = confidence interval.
  2. A negative value indicates a decrease in day 28 values, on average compared to baseline.
  3. *p-value from ANCOVA test of difference at day 28 between arms adjusting for baseline values.