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Table 5 Drug questionnaire response

From: Efficacy and safety of artemether-lumefantrine and dihydroartemisinin-piperaquine in the treatment of uncomplicated Plasmodium falciparum malaria in Kenyan children aged less than five years: results of an open-label, randomized, single-centre study

  AL dispersible N = 126 DP paediatric N = 124 p-value*
Regimen, median number of tablets required  6  4  
Pack available for survey, n (%) 117 (93.6) 107 (85.6) 0.089
Acceptability and comprehension  
Health worker explained how to administer drug, n (%) 124 (99.2) 122 (98.4) 0.684
Health worker used pictures to explain how to administer drug, n (%) 123 (99.2) 123 (99.2) 0.321
Pictures helped in understanding how to administer, n (%) 124 (99.2) 124 (99.2) 0.159
Difficulty/Ease of using drug    0.001
 Very difficult, n (%)  0  3 (2.4)
 Difficult, n (%)  2 (1.6)  10 (8.1)
 Acceptable, n (%)  19 (15.2)  28 (22.6)
 Simple, n (%)  85 (68.0)  56 (45.2)
 Very simple, n (%)  18 (14.4)  27 (21.8)
Difficulty/Ease of using drug A compared to B    0.007
 Very difficult, n (%) - -
 Difficult, n (%)  3 (2.4)  11 (8.9)
 Acceptable, n (%)  25 (20.0)  28 (22.6)
 Simple, n (%)  82 (65.6)  59 (47.6)
 Very simple, n (%)  14 (11.2)  26 (21.0)
Taste of medicine for child    0.001
 Not at all, n (%)  0  4 (3.2)
 Not very much, n (%)  11 (8.8)  24 (19.4)
 Acceptable, n (%)  23 (18.4)  25 (20.2)
 Liked it, n (%)  80 (64.0)  50 (40.3)
 Liked it very much, n (%)  10 (8.0)  20 (16.1)
Liquid for dissolving tablet    0.301
 Water, n (%) 119 (95.4) 115 (92.7)
 Other, n (%)  6 (4.6) 10 (7.3)
Drug taken with a meal, n (%) 118 (94.4) 110 (89.4)  
Prefer drug given as    0.025
 Syrup, n (%)  21 (16.8)  36 (29.5)
 Whole tablet which dissolves in small volume of water/milk, n (%)  96 (76.8)  76 (62.3)
 Injection, n (%)  2 (1.6)  7 (5.7)
 Other, n (%)  6 (4.8)  8 (6.4)
Prefer other anti-malarias, n (%)  4 (3.2)  5 (4.0)  
Perceived adverse drug reactions  
Anything unusual after medication given, n (%)  4 (3.2)  1 (0.8)  
Concomitant medication given, n (%)  3 (2.6)  2 (1.9)  
Adverse reaction solicited, n (%)  2 (1.7)  1 (0.9)  
Caretaker reported ADR to health worker, n (%)  2 (1.7)  1 (0.9)  
ADR/SAE completed based on events seriousness, n (%)  1 (0.9)  1 (0.9)  
  1. AL: artemether-lumefantrine; DP: dihydroartemisinin-piperaquine.