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Table 5 Drug questionnaire response

From: Efficacy and safety of artemether-lumefantrine and dihydroartemisinin-piperaquine in the treatment of uncomplicated Plasmodium falciparum malaria in Kenyan children aged less than five years: results of an open-label, randomized, single-centre study

 

AL dispersible N = 126

DP paediatric N = 124

p-value*

Regimen, median number of tablets required

 6

 4

 

Pack available for survey, n (%)

117 (93.6)

107 (85.6)

0.089

Acceptability and comprehension

 

Health worker explained how to administer drug, n (%)

124 (99.2)

122 (98.4)

0.684

Health worker used pictures to explain how to administer drug, n (%)

123 (99.2)

123 (99.2)

0.321

Pictures helped in understanding how to administer, n (%)

124 (99.2)

124 (99.2)

0.159

Difficulty/Ease of using drug

  

0.001

 Very difficult, n (%)

 0

 3 (2.4)

 Difficult, n (%)

 2 (1.6)

 10 (8.1)

 Acceptable, n (%)

 19 (15.2)

 28 (22.6)

 Simple, n (%)

 85 (68.0)

 56 (45.2)

 Very simple, n (%)

 18 (14.4)

 27 (21.8)

Difficulty/Ease of using drug A compared to B

  

0.007

 Very difficult, n (%)

-

-

 Difficult, n (%)

 3 (2.4)

 11 (8.9)

 Acceptable, n (%)

 25 (20.0)

 28 (22.6)

 Simple, n (%)

 82 (65.6)

 59 (47.6)

 Very simple, n (%)

 14 (11.2)

 26 (21.0)

Taste of medicine for child

  

0.001

 Not at all, n (%)

 0

 4 (3.2)

 Not very much, n (%)

 11 (8.8)

 24 (19.4)

 Acceptable, n (%)

 23 (18.4)

 25 (20.2)

 Liked it, n (%)

 80 (64.0)

 50 (40.3)

 Liked it very much, n (%)

 10 (8.0)

 20 (16.1)

Liquid for dissolving tablet

  

0.301

 Water, n (%)

119 (95.4)

115 (92.7)

 Other, n (%)

 6 (4.6)

10 (7.3)

Drug taken with a meal, n (%)

118 (94.4)

110 (89.4)

 

Prefer drug given as

  

0.025

 Syrup, n (%)

 21 (16.8)

 36 (29.5)

 Whole tablet which dissolves in small volume of water/milk, n (%)

 96 (76.8)

 76 (62.3)

 Injection, n (%)

 2 (1.6)

 7 (5.7)

 Other, n (%)

 6 (4.8)

 8 (6.4)

Prefer other anti-malarias, n (%)

 4 (3.2)

 5 (4.0)

 

Perceived adverse drug reactions

 

Anything unusual after medication given, n (%)

 4 (3.2)

 1 (0.8)

 

Concomitant medication given, n (%)

 3 (2.6)

 2 (1.9)

 

Adverse reaction solicited, n (%)

 2 (1.7)

 1 (0.9)

 

Caretaker reported ADR to health worker, n (%)

 2 (1.7)

 1 (0.9)

 

ADR/SAE completed based on events seriousness, n (%)

 1 (0.9)

 1 (0.9)

 
  1. AL: artemether-lumefantrine; DP: dihydroartemisinin-piperaquine.