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Figure 2 | Malaria Journal

Figure 2

From: A novel approach for the discovery of chemically diverse anti-malarial compounds targeting the Plasmodium falciparum Coenzyme A synthesis pathway

Figure 2

Coenzyme A rescues panthenol-induced Plasmodium falciparum growth inhibition. A: Confirmation of panthenol as a dose-dependent P. falciparum growth inhibitor; graphs represent n = 3, triplicate point each; error bars indicate +/- standard error of mean (SEM). B: Supplementation of CoA concentrations of 1 and 2 mM rescued panthenol-induced growth inhibition; graphs represent n = 3, triplicate point each; error bars indicate +/- standard error of mean (SEM). C: Parasite growth was not significantly altered by supplementation of CoA alone; graphs represent n = 3, triplicate point each; error bars indicate +/- standard error of mean (SEM).Different batches of CoA purchased throughout the course of this study varied in their ability to rescue the parasites, as well as varying in degrees of toxicity at higher concentrations. As a consequence, and to ensure comparable results were obtained, the CoA concentration used in each experiment was adjusted to an optimal rescue concentration for each CoA batch. The optimal rescue concentration varied from 0.8 to 2 mM.

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