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Figure 3 | Malaria Journal

Figure 3

From: A novel approach for the discovery of chemically diverse anti-malarial compounds targeting the Plasmodium falciparum Coenzyme A synthesis pathway

Figure 3

Compound activity at 2 μM with and without supplementation of Coenzyme A. A: Confirmed hits at 2 μM compound concentration. Direct comparison of compound activity with (black) and without (grey) addition of CoA. Shown are the original hits from compound library plates and two re-tests from purchased solids. Four compounds showed rescue levels of over 80% of untreated control values and two more of just below 80% when CoA was added; original hit bar graphs show n = 2, duplicate point for hits originating from the focussed compound library and n = 1, single point for compounds of the MMV malaria box. Re-test bar graphs show n = 1; duplicate point each; error bars indicate +/- standard error of mean (SEM). B: Confirmed hit with rescue to >50% of untreated control value at a 2 μM compound concentration. The original hit bar graph shows n = 2, duplicate point. Both re-test bar graphs show n = 1; duplicate point each; error bars indicate +/- standard error of mean (SEM).

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Malaria Journal

ISSN: 1475-2875

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