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Figure 8 | Malaria Journal

Figure 8

From: A novel approach for the discovery of chemically diverse anti-malarial compounds targeting the Plasmodium falciparum Coenzyme A synthesis pathway

Figure 8

Exemplary time course (compound Amb180780) for parasite stage of action and phenotypic investigation. A: Parasites treated with Amb180780 (solid green line) appear to be arrested at the ring stage throughout the time course. CoA addition rescues the progression through the parasite stages (dashed green line); graphs show n = 1, the Giemsa smear was taken from 16 pooled replicate wells. A minimum of 100 parasites were phenotypically assessed for each time point. Relative parasitaemia values are shown. B: Representative Giemsa stained bright field microscopic images showing the predominant parasite phenotype at each time point for compound treatment (top panel) and DMSO control (bottom panel). Scale bar 5 μm.

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