Meta-analysis summary of the relationship between malaria risk and allele frequency. Local malaria risk (only endemic countries) is shown on the left and global estimates of risk (all countries) on the right. On the top, effect sizes are grouped into supertypes. Statistical results demonstrate whether supertype-specific effect sizes are significantly different within a particular locus. Comparisons of effect sizes across loci are shown on the bottom. Squares and horizontal lines show mean effect sizes (r) and the associated 95% confidence intervals (95% CI), respectively. Diamonds summarize the entire data (vertical endpoints: overall mean effect size, horizontal endpoints: 95% CI). N is the number of alleles.