Figure 1

Survival of TLR-deficient mice during cerebral malaria. (A) C57BL/6 (B6), Tlr7^-/-, Tlr9^-/-, Tlr7^-/-Tlr9^-/-, and Myd88^-/- mice were challenged with 10⁶P. berghei erythrocytes and monitored daily for survival (n = 63 B6, n = 71 Tlr7^-/-, n = 45 Tlr9^−/−, n = 25 Tlr7^-/-Tlr9^-/-, n = 38 Myd88^−/−). *, p < 0.05 (log rank [Mantel-Cox] test). Data were pooled from six experiments. (B) Infected C57Bl/6, Tlr7^−/−, Tlr9^-/-, and Myd88^−/− mice were monitored for parasitaemia. Right, zoomed-in plot of region contained within gray box on left. (n = 25 B6, n = 25 Tlr7^-/-, n = 16 Tlr9^−/−; n = 21 Myd88^−/−). Data were pooled from three independent experiments.