Skip to main content

Table 3 Univariate and multivariate analysis of the association between different neurological phenotypes of severe malaria and scores for executive functioning tests in children

From: Impairment of executive function in Kenyan children exposed to severe falciparum malaria with neurological involvement

Phenotypes of severe malaria Vigilance efficiency scores, β (95% CI) TEA-Ch test total scores, β (95% CI) Contingency naming test average total error scores, β (95% CI) Contingency naming test average efficiency scores, β (95% CI) Self-ordered pointing test, β (95% CI)
Impaired consciousness: unadjusted model 0.02 (-0.12-0.18); P = 0.734 0.09 (-0.33-0.51); P = 0.667 -0.07 (-0.28-0.14); P = 0.494 0.07 (-0.02-0.16); P = 0.110 0.47 (-2.73-3.67); P = 0.771
Impaired consciousness: adjusted model 0.03 (-0.14-0.20); P = 0.756 -0.40 (-0.81-0.01); P = 0.058 0.08 (-0.35-0.19); P = 0.542 0.06 (-0.06-0.18); P = 0.329 0.99 (-3.12-5.11); P = 0.628
Complex seizures: unadjusted model -0.35 (-0.59--0.10); P = 0.006 -0.27 (-0.81-0.27); P = 0.318 -0.04 (-0.36-0.28); P = 0.808 -0.01 (-0.12-0.12); P = 0.919 4.70 (0.50-8.90); P = 0.029
Complex seizures: adjusted model -0.47 (-0.67--0.13); P = 0.006 -0.57 (-1.04--0.10); P = 0.019 -0.59 (-0.20-0.08); P = 0.411 0.10 (-0.32-0.52); P = 0.629 4.57 (-0.73-9.89); P = 0.089
Seizures with fever: unadjusted model -0.16 (-0.53-0.21);P = 0.377 -0.44 (-1.40-0.52); P = 0.361 0.07 (-0.46-0.60); P = 0.802 0.09 (-0.10-0.27); P = 0.342 5.20 (-1.64-12.05); P = 0.133
Seizures with fever: adjusted model -0.06 (-0.50-0.37); P = 0.763 -0.42 (-1.34-0.50); P = 0.352 0.18 (-0.62-0.98); P = 0.647 0.04 (-0.21-0.29); P = 0.746 2.72 (-6.07-2.59); P = 0.529
Prostration: unadjusted model -0.00 (-0.25-0.25); P = 0.994 0.33 (-0.35-1.01); P = 0.339 -0.05 (-0.42-0.33); P = 0.800 0.10 (-0.03-0.22); P = 0.142 1.31 (-3.19-5.82); P = 0.562
Prostration: adjusted model -0.01 (-0.26-0.25); P = 0.963 0.21 (-0.38-0.81); P = 0.474 -0.11 (-0.62-0.39); P = 0.653 0.10 (-0.06-0.25); P = 0.205 1.59 (-3.86-7.05); P = 0.555
All phenotypes: unadjusted model -0.08 (-0.23-0.05); P = 0.219 0.01 (-0.34-0.34); P = 0.989 -0.05 (-0.23-0.12); P = 0.575 0.06 (-0.01-0.13); P = 0.090 1.98 (-0.74-4.69); P = 0.152
All phenotypes: adjusted model -0.13 (-0.13-0.04); P = 0.137 -0.29 (-0.66-0.07); P = 0.109 -0.03 (-0.26-0.20); P = 0.800 0.04 (-0.05-0.13); P = 0.408 2.00 (-1.28-5.29); P = 0.229
  1. TEA = test of everyday attention; β = beta coefficient; CI = confidence interval; associations were performed using linear regression, with multivariate analysis adjusted for a child’s age, sex, schooling; maternal age, schooling and economic activity; perinatal adverse events and history of seizures.