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Table 1 The modelled nadir and % reductions in pararasite prevalence (% infected with P. falciparum ) in the year following one (*1) or two (*2) annual rounds of MDA using atovaquone-proguanil or ACT +/− primaquine in western Cambodia

From: The diminishing returns of atovaquone-proguanil for elimination of Plasmodium falciparum malaria: modelling mass drug administration and treatment

MDA strategy used

Nadir parasite prevalence (%)

% decrease in nadir with MDA

Nil

8.9

 

Atovaquone-proguanil*1

4.8

45.6

(Atovaquone-proguanil + primaquine)*1

4.6

48.7

Atovaquone-proguanil*2

3.9

56.2

(Atovaquone-proguanil + primaquine)*2

3.5

60.4

ACT*1

5.1

43.1

(ACT + primaquine)*1

4.7

47.7

ACT*2

4.0

55.4

(ACT + primaquine)*2

3.5

60.9

  1. In the examples shown, the MDA was done at the time of maximum efficacy (1–2 months before nadir parasite prevalence).
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Malaria Journal

ISSN: 1475-2875

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