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Table 1 The modelled nadir and % reductions in pararasite prevalence (% infected with P. falciparum ) in the year following one (*1) or two (*2) annual rounds of MDA using atovaquone-proguanil or ACT +/− primaquine in western Cambodia

From: The diminishing returns of atovaquone-proguanil for elimination of Plasmodium falciparum malaria: modelling mass drug administration and treatment

MDA strategy used Nadir parasite prevalence (%) % decrease in nadir with MDA
Nil 8.9  
Atovaquone-proguanil*1 4.8 45.6
(Atovaquone-proguanil + primaquine)*1 4.6 48.7
Atovaquone-proguanil*2 3.9 56.2
(Atovaquone-proguanil + primaquine)*2 3.5 60.4
ACT*1 5.1 43.1
(ACT + primaquine)*1 4.7 47.7
ACT*2 4.0 55.4
(ACT + primaquine)*2 3.5 60.9
  1. In the examples shown, the MDA was done at the time of maximum efficacy (1–2 months before nadir parasite prevalence).