Low genetic diversity in the locus encoding the Plasmodium vivax P41 protein in Colombia’s parasite population

Malaria Journal

Table 4 McDonald-Kreitman test for evaluating the action of natural selection on the p41 gene

	P. vivax/P. cynomolgi			P. vivax/P. knowlesi
Worldwide isolates	Fixed	Polymorphic	NI (p-values)	Fixed	Polymorphic	NI (p-values)
Non-synonymous substitutions	45.62	11	4.45 (0.003)	61.95	11	4.12 (0.004)
Synonymous substitutions	110.71	6	4.45 (0.003)	138.81	6	4.12 (0.004)
Colombian isolates
Non-synonymous substitutions	46.69	8	9.65 (0.000)	63.06	8	8.80 (0.001)
Synonymous substitutions	112.65	2	9.65 (0.000)	138.81	2	8.80 (0.001)

The McDonald-Kreitman test involved using the sequences obtained from the databases together with the Colombian ones (worldwide isolates), and just those obtained in the Colombian population (Colombian isolates). The data regarding divergence between species was obtained by comparing P. vivax sequences to that from two related species: P. cynomolgi and P. knowlesi. NI: neutral index.

ISSN: 1475-2875