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Table 1 1 H NMR data of related impurity 6 of piperaquine phosphate

From: Stability profiling of anti-malarial drug piperaquine phosphate and impurities by HPLC-UV, TOF-MS, ESI-MS and NMR

Positiona Number of protons Proton chemical shift, δH Jb(/Hz)
1, 1′ - - -
2, 2′ 2 8.88 8.45, d
3, 3′ 2 7.48 6.35, d
4, 4′ - - -
5, 5′ 2 8.20 8.33, d
6, 6′ 2 7.77 9.0, d
7, 7′ - - -
8, 8′ 2 8.27 6.36, d
9, 9′ - - -
10, 10′ - - -
11 - - -
12 4 4.35 ~ 4.37 m
13 4 4.26 ~ 4.28 m
14 - - -
15 2 3.71 br
16 2 2.73 br
17 2 3.46 br
18 - - -
19 4 4.07 ~ 4.12 m
20 4 4.16 ~ 4.21 m
  1. aRefer the structural formula in Figure 6 for numbering.
  2. b1H-1H coupling constants.