Stability profiling of anti-malarial drug piperaquine phosphate and impurities by HPLC-UV, TOF-MS, ESI-MS and NMR

Malaria Journal

Table 1 ¹ H NMR data of related impurity 6 of piperaquine phosphate

Position^a	Number of protons	Proton chemical shift, δ_H	J^b(/Hz)
1, 1′	-	-	-
2, 2′	2	8.88	8.45, d
3, 3′	2	7.48	6.35, d
4, 4′	-	-	-
5, 5′	2	8.20	8.33, d
6, 6′	2	7.77	9.0, d
7, 7′	-	-	-
8, 8′	2	8.27	6.36, d
9, 9′	-	-	-
10, 10′	-	-	-
11	-	-	-
12	4	4.35 ~ 4.37	m
13	4	4.26 ~ 4.28	m
14	-	-	-
15	2	3.71	br
16	2	2.73	br
17	2	3.46	br
18	-	-	-
19	4	4.07 ~ 4.12	m
20	4	4.16 ~ 4.21	m

ISSN: 1475-2875