Skip to main content

Table 2 1 H, 13 C NMR data of related impurity (2 and 12) of piperaquine phosphate

From: Stability profiling of anti-malarial drug piperaquine phosphate and impurities by HPLC-UV, TOF-MS, ESI-MS and NMR

  2 12
Positiona δH(Jb/Hz) δC δH(Jb/Hz) δC
1 - - - -
2 7.95 (1H, d, 7.4) 139.9 8.45 (2H, d, 7.1) 144.5
3 6.10 (1H, d, 7.4) 109.2 7.09 (2H, d, 7.2) 107.2
4 11.91 (1H, s) 176.2 - 164.2
5 8.11 (1H, d, 8.7) 127.2 8.33 (2H, d, 9.3) 131.4
6 7.33 (1H, d, 10) 123.4 7.71 (2H, d, 7.8) 131.0
7 - 136.2 - 121.7
8 7.63 (1H, s) 117.4 8.07 (2H, d, 1.7) 122.8
9 - 140.8 - 143.4
10 - 124.3 - 120.4
11 - - - -
12 - - 4.48 (8H, s) 52.9
  1. aRefer the structural formula in Figure 6 for numbering.
  2. b1H-1H coupling constants.