Genetic mutations in Plasmodium falciparum and Plasmodium vivax dihydrofolate reductase (DHFR) and dihydropteroate synthase (DHPS) in Vanuatu and Solomon Islands prior to the introduction of artemisinin combination therapy

Table 2 Amino acid substitutions (bold) and prevalence in P. vivax DHFR and DHPS from Vanuatu and Solomon Islands

PvDHFR
Amino acid position		n	Frequency	33	57	58	61	117	173
Wild type				P	F	S	T	S	I
Known substitutions in the region				L	I/L	R	N	T/N	L
Country	Island/province
Vanuatu	Tanna Is.	51	33	P	F	R	T	N	I
			11	P	M	S	T	T	F
			7	P	L	S	T	S	F
Solomon Is	Temotu Prov.	40	32	P	L	R	M	T	I
			4	P	F	S	T	N	I
			3	P	L	R	T	T	I
			1	P	L	R	T	S	M
	Malaita Prov.	46	39	P	L	R	M	T	I
			3	P	L	R	T	S	M
			2	P	F	R _AGA	T	N	I
			1	P	L	R	T	N	I
			1	P	F	R _AGA	T	T	I
PvDHPS
Amino acid position		n	Frequency	382	383	512	553	585
Wild type				S	A	K	A	V
Known substitutions in the region					G		G
Country	Island/province
Vanuatu	Tanna Is.	38	38	S	A	K	A	V
Solomon Is	Temotu Prov.	22	22	S	A	K	A	V
	Malaita Prov.	48	48	S	A	K	A	V